About: Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China

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About: Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China
Creator	Cai, Yin Jiang, Fang Xia, Zhengyuan Jin, Wei Wang, Bo Shi, Yuan Gao, Shan Yang, Leilei Lin, Han Peng, Jian Jia, Linyan Xia, Yanqiong
Source	Medline; PMC
abstract	The mortality rate of elderly patients with Coronavirus Disease 2019 (COVID-19) was significantly higher than the overall mortality rate. However, besides age, leading death risk factors for the high mortality in elderly patients remain unidentified. This retrospective study included 210 elderly COVID-19 patients (aged ≥ 65 years), of whom 175 patients were discharged and 35 died. All deceased patients had at least one comorbidity. A significantly higher proportion of patients in the deceased group had cardiovascular diseases (49% vs. 20%), respiratory diseases (51% vs. 11%), chronic kidney disease (29% vs. 5%) and cerebrovascular disease (20% vs. 3%) than that in the discharged group. The median levels of C-reactive protein (125.8mg/L vs. 9.3mg/L) and blood urea nitrogen (7.2mmol/L vs. 4.4mmol/L) were significantly higher and median lymphocyte counts (0.7×10(9)/L vs. 1.1×10(9)/L) significantly lower in the deceased group than those in the discharged group. The survival curve analysis showed that higher C-reactive protein (≥5mg/L) plus any other abnormalities of lymphocyte, blood urea nitrogen or lactate dehydrogenase significantly predicted poor prognosis of COVID-19 infected elderly patients. This study revealed that the risk factors for the death in these elderly patients included comorbidities, increased levels of C-reactive protein and blood urea nitrogen, and lymphopenia during hospitalization.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.18632/aging.103631
bibo:pmid	32651993
has license	cc-by
sha1sum (hex)	ecaeb9830d9852ca18e6a1b2aa60a7acea603a7e
schema:url	https://doi.org/10.18632/aging.103631
resource representing a document's title	Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China
has PubMed Central identifier	PMC7377843
has PubMed identifier	32651993
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:ecaeb9830d9852ca18e6a1b2aa60a7acea603a7e#body_text
is schema:about of	named entity 'patients' named entity 'comorbidities' named entity 'This' named entity 'COVID-19' named entity 'Risk factors' named entity 'HIGH' named entity 'CEREBROVASCULAR DISEASE' named entity 'PROPORTION' named entity 'RETROSPECTIVE STUDY' named entity 'ANALYSIS' named entity 'AGE' named entity 'RISK FACTORS' named entity 'CHINA' named entity 'COVID-19' named entity 'mortality rate' named entity 'elderly' named entity 'discharged' named entity 'All' named entity 'levels' named entity 'risk factors' named entity 'discharged' named entity 'patients' named entity 'C-reactive protein' named entity 'patients' named entity 'comorbidity' named entity 'elderly patients' named entity 'lymphocyte' named entity 'elderly patients' named entity 'C-reactive protein' named entity 'chronic kidney disease' named entity 'lactate dehydrogenase' named entity 'survival curve' named entity 'prognosis' named entity 'elderly patients' named entity 'comorbidities' named entity 'mortality rate' named entity 'C-reactive protein' named entity 'COVID-19' named entity 'Risk factors' named entity 'prognosis' named entity 'chi-square test' named entity 'risk factor' named entity 'lymphocyte' named entity 'acute respiratory distress syndrome' named entity 'elderly people' named entity 'C-reactive protein' named entity 'interquartile range' named entity 'Stroke' named entity 'CRP' named entity 'symptom' named entity 'ground glass opacities' named entity 'AUC' named entity 'serum creatinine' named entity 'AUC' named entity 'fatigue' named entity 'BUN' named entity 'mortality rate' named entity 'clinical practice guidelines' named entity 'clinical research' named entity 'lymphocyte' named entity 'prognosis' named entity 'nausea' named entity 'BUN' named entity 'glucose' named entity 'alveolar epithelial cells' named entity 'Respiratory failure' named entity 'postmenopausal' named entity 'COVID' named entity 'LDH' named entity 'COVID-19 response'

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