About: Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity

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About: Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity
Creator	Song, Kyoung-Ho Kim, Minji Kim, Nam-Joong Oh, Myoung-Don Kim, Gwanghun Choe, Gyun Choe, Pyoeng Kim, Eu Kim, Hong Kim, Suk Park, Wan Shin, Hyun Kang, Chang Han, Gi-Chan Kim, Hang-Rae
source	Elsevier; Medline; PMC
abstract	Abstract Objectives We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases. Methods We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation ≤ 93% at room air. Expressions of molecules related to T-cell activation and functions were analyzed by flow cytometry. Results The population dynamics of T cells at the first week were not different between the two groups. However, total numbers of CD4+ and CD8 + T cells tended to be lower in the severe group at the third week of illness. Expressions of Ki-67, PD-1, perforin, and granzyme B in CD4+ or CD8+ T cells were significantly higher in the severe group than in the mild group at the third week. In contrast to the mild group, the levels of their expression did not decrease in severe group. Conclusions Severe COVID-19 had higher degree of proliferation, activation, and cytotoxicity of T-cells at the late phase of illness without cytotoxic T-cell contraction, which might contribute to the development of severe COVID-19.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.05.106
bibo:pmid	32492530
has license	els-covid
sha1sum (hex)	ebc9df3be57a45625c703a3451bc86ee32e13382
schema:url	https://doi.org/10.1016/j.ijid.2020.05.106
resource representing a document's title	Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity
has PubMed Central identifier	PMC7261468
has PubMed identifier	32492530
schema:publication	Int J Infect Dis
resource representing a document's body	covid:ebc9df3be57a45625c703a3451bc86ee32e13382#body_text
is schema:about of	named entity 'illness' named entity 'Cytotoxic T-cell' named entity 'LOADS' named entity 'CELLULAR' named entity 'ACTIVATION' named entity 'OBJECTIVES' named entity 'CELL' named entity 'SEVERE COVID-19' named entity 'N A' named entity 'cases' named entity 'T-cell' named entity 'hyperactivation' named entity 'responses' named entity 'groups' named entity 'cell-mediated' named entity 'COVID-19' named entity 'immune response' named entity 'PBMCs' named entity 'T-cell' named entity 'COVID-19' named entity 'cytotoxic T-cell' named entity 'hyperactivation' named entity 'Cytotoxic T-cell' named entity 'determinant' named entity 'viral shedding' named entity 'granzyme' named entity 'IFN-γ' named entity 'PBMCs' named entity 'COVID-19' named entity 'perforin' named entity 'CD8 +' named entity 'Life Technologies' named entity 'SARS' named entity 'Alexa Fluor' named entity 'expression levels' named entity 'FoxP3' named entity 'PD-1' named entity 'cytokines' named entity 'CD8 +' named entity 'fluorescence' named entity 'ICU' named entity 'BD Biosciences' named entity 'interquartile range' named entity 'PD-1' named entity 'Tcell' named entity 'intensive care unit' named entity 'IL-15' named entity 'Windows' named entity 'San Diego' named entity 'COVID-19' named entity 'perforin' named entity 'Ki-67' named entity 'COVID-19' named entity 'paraformaldehyde' named entity 'expression levels' named entity 'cytotoxic' named entity 'allophycocyanin' named entity 'CD4' named entity 'peripheral blood mononuclear cells' named entity 'ionomycin' named entity 'granzyme' named entity 'liquid nitrogen' named entity 'HLA-DR' named entity 'virus' named entity 'antigen' named entity 'FITC' named entity 'cytotoxicity'

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