About: Prevalence of porcine circovirus type 3 in pigs in the southeastern Chinese province of Zhejiang

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About: Prevalence of porcine circovirus type 3 in pigs in the southeastern Chinese province of Zhejiang Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence of porcine circovirus type 3 in pigs in the southeastern Chinese province of Zhejiang
Creator	Chen, Cong Chen, Yunlu Fang, Weihuan Geng, Shichao Li, Xiaoliang Liu, Yajie Luo, Hao Xu, Weicheng
topic	covid:e9a9765d57cbca2e0c985f6fdcd04de38b0384cf#this
Source	Medline; PMC
abstract	BACKGROUND: Porcine circovirus type 3 (PCV3) was first reported in US in 2016. The virus was also identified later in China. Prevalence of PCV3 in Zhejiang province in southeastern China is not clear though it has been reported in many parts of China. RESULTS: PCV3 infection and its co-infection with other swine viral pathogens in pig herds of Zhejiang province were retrospectively investigated by quantitative PCR (qPCR) and its sero-prevalence by indirect ELISA. PCV3 was found positive in 67.1% of the 283 clinical samples taken from 2014 to 2017 as shown by qPCR. Single infection with PCV3 accounted for only one-third of the samples, and majority were of co-infections, predominantly with PEDV (41.6%) but generally low with other swine viruses. Indirect ELISA using the PCV3 capsid protein as the coating antigen revealed an average sero-positive rate of 52.6% (40.8 to 60.8%) in 2345 serum samples from 2011 to 2017, with earliest yet high positive findings in samples taken in 2012. Of 203 serum samples, the qPCR method showed more positive findings than ELISA (81.3% vs 56.2%). With 89 serum samples negative by ELISA, vast majority (n = 81) were found positive by qPCR. There was negative correlation in levels of PCV3 DNA and anti-capsid antibody response. ORF2-based phylogenetic analysis revealed three major groups (PCV3a, PCV3b and PCV3c) of the 200 strains, 38 from this study and 162 reference strains from GenBank. Most of the strains from this study were clustered into PCV3c. Of the putative signature residues of the capsid protein (aa 24, 27, 77 and 150) relative to the three groups, only the PCV3a group strains showed a distinct pattern of residues VKSI (95% of the strains), while the other two groups did not have such a ‘signature’ pattern. CONCLUSIONS: Results from this study provided further evidence that the novel virus PCV3 was widely distributed in China and might have emerged in Zhejiang province before 2014, most probably back in 2012 when there was high PCV3 sero-prevalence. PCV3 might be viremic in pigs and could spread by fecal shedding. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-019-1977-7) contains supplementary material, which is available to authorized users.
has issue date	2019-07-15(xsd:dateTime)
bibo:doi	10.1186/s12917-019-1977-7
bibo:pmid	31307451
has license	cc-by
sha1sum (hex)	e9a9765d57cbca2e0c985f6fdcd04de38b0384cf
schema:url	https://doi.org/10.1186/s12917-019-1977-7
resource representing a document's title	Prevalence of porcine circovirus type 3 in pigs in the southeastern Chinese province of Zhejiang
has PubMed Central identifier	PMC6631677
has PubMed identifier	31307451
schema:publication	BMC Vet Res
resource representing a document's body	covid:e9a9765d57cbca2e0c985f6fdcd04de38b0384cf#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e9a9765d57cbca2e0c985f6fdcd04de38b0384cf
is schema:about of	named entity 'CHINESE' named entity 'virus' named entity 'type 3' named entity 'coating' named entity 'samples' named entity 'distributed' named entity '2017' named entity 'positive' named entity 'type 3' named entity 'porcine circovirus' named entity 'Chinese province' named entity 'EVIDENCE' named entity 'BASED' named entity 'VIRUS' named entity 'PARTS' named entity 'SPREAD' named entity 'PREVALENCE' named entity 'DNA' named entity 'RELATIVE TO' named entity 'LOW' named entity 'REFERENCE' named entity '200' named entity 'PROTEIN ' named entity 'CLINICAL' covid:arg/e9a9765d57cbca2e0c985f6fdcd04de38b0384cf named entity 'INDIRECT' named entity 'LATER' named entity 'ANTIBODY RESPONSE' named entity 'PEDV' named entity 'MAJOR' named entity '2011' named entity 'GROUP' named entity 'PIGS' named entity 'PORCINE CIRCOVIRUS TYPE 3' named entity 'CAPSID PROTEIN' named entity 'COATING' named entity 'QUANTITATIVE PCR' named entity 'SOUTHEASTERN' named entity 'PROVINCE' named entity 'CO-INFECTIONS' named entity 'SWINE' named entity 'SINGLE INFECTION' named entity 'CONCLUSIONS' named entity 'VIRAL PATHOGENS' named entity 'IDENTIFIED' named entity 'CLEAR' named entity 'INFECTION' named entity 'USING' named entity 'NOVEL' named entity '203' named entity 'ORF2' named entity 'GENBANK' named entity 'PHYLOGENETIC ANALYSIS' named entity 'CORRELATION' named entity 'DISTINCT' named entity 'SERUM' named entity 'ITS' named entity 'POSITIVE RATE' named entity 'RESULTS' named entity 'STRAINS' named entity 'MOST OF' named entity 'METHOD' named entity 'PORCINE CIRCOVIRUS TYPE 3' named entity 'FECAL' named entity 'CHINA' named entity 'PIG' named entity 'SOUTHEASTERN' named entity 'LEVELS' named entity 'AVERAGE' named entity 'VIRUSES' named entity 'INVESTIGATED' named entity 'PIGS'

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