About: Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain

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About: Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain
Creator	Zhao, Jing Zhao, Ye Chen, Yang Xu, Gang Pei, Jianwu Zhang, Guo-Zhong Adachi, Akio Fuller, Frederick G-Z, Zhang Yan, Shi-Hong
topic	covid:e99a0adb1aa26558acfc74fa0c7197a8a591b6ef#this
Source	Medline; PMC
abstract	Avian infectious bronchitis, a highly contagious disease caused by avian infectious bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China in recent years; hence, evaluating their pathogenicity and developing a specific vaccine to guard against their potential threat to the poultry industry is important. Here, we examined the pathogenicity of a TW-like IBV strain (GD), and evaluated the protective efficacy of the QX-like strain (JS) against GD in challenge infections in chickens. The results revealed that strain-GD-infected birds experienced severe respiratory signs, renal lesions, and 30–40% mortality. The GD virus had extensive tissue tropism, especially in the trachea, lungs, kidneys, and bursa of Fabricius, and was continuously shed via the respiratory tract and cloaca. The QX-like IBV strain JS is able to completely protect chickens from challenge with the TW-like IBV GD field strain, with no clinical signs or gross lesions, decreased tissue replication rates, lower ciliostasis score, and reduced virus shedding. These findings indicate that IBV GD is highly virulent, and that QX-like JS may serve as an effective vaccine against the threat posed by IBV TW-like viruses.
has issue date	2016-10-18(xsd:dateTime)
bibo:doi	10.3389/fmicb.2016.01653
bibo:pmid	27803698
has license	cc-by
sha1sum (hex)	e99a0adb1aa26558acfc74fa0c7197a8a591b6ef
schema:url	https://doi.org/10.3389/fmicb.2016.01653
resource representing a document's title	Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain
has PubMed Central identifier	PMC5067408
has PubMed identifier	27803698
schema:publication	Front Microbiol
resource representing a document's body	covid:e99a0adb1aa26558acfc74fa0c7197a8a591b6ef#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/e99a0adb1aa26558acfc74fa0c7197a8a591b6ef
is schema:about of	named entity 'tissue' named entity 'infectious bronchitis' named entity 'serve' named entity 'chickens' named entity 'Fabricius' named entity 'effective' named entity 'vaccine' named entity 'IBV' named entity 'potential' named entity 'EVALUATION' named entity 'POULTRY INDUSTRY' covid:arg/e99a0adb1aa26558acfc74fa0c7197a8a591b6ef named entity 'PATHOGENICITY' named entity 'SIGNS' named entity 'INDUCED' named entity 'LIKE' named entity 'RECENT' named entity 'VIRULENT' named entity 'EXPERIENCED' named entity 'EFFECTIVE' named entity 'FIELD' named entity 'CONSIDERABLE' named entity 'TISSUE' named entity 'CLOACA' named entity 'KIDNEYS' named entity 'DEVELOPING' named entity 'TISSUE TROPISM' named entity 'TRACHEA' named entity 'FINDINGS' named entity 'THEIR' named entity 'RESPIRATORY' named entity 'CHALLENGE' named entity 'RESPIRATORY TRACT' named entity 'YEARS' named entity 'CAUSED BY' named entity 'LESIONS' named entity 'COMPLETELY' named entity 'HAVE' named entity 'EXTENSIVE' named entity 'PROTECTION' named entity 'STRAIN' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'SPECIFIC' named entity 'RENAL' named entity 'VACCINE' named entity 'EXAMINED' named entity 'HERE' named entity 'PATHOGENICITY' named entity 'HIGHLY' named entity 'INFECTIONS' named entity 'SCORE' named entity 'POTENTIAL' named entity 'RESULTS' named entity 'EVALUATING' named entity 'SEVERE' named entity 'CHINA' named entity 'HIGHLY CONTAGIOUS DISEASE' named entity 'LUNGS' named entity 'GROSS LESIONS' named entity 'DECREASED' named entity 'REVEALED' named entity 'IMPORTANT' named entity 'VIRUS' named entity 'RATES' named entity 'THREAT' named entity 'SERVE' named entity 'VIRUSES' named entity 'REDUCED' named entity 'EFFICACY' named entity 'EVALUATED'

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