About: Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors
Creator	Zhang, Zheng Ge, Xingyi Jiang, Taijiao Peng, Yousong Zhu, Zhaozhong Wu, Aiping Tan, Zhongyang Zhu, Haizhen Cai, Zena Chen, Wenjun Xia, Zanxian Tan, Zhiying Guo, Xinhong Xu, Beibei
Source	Medline; PMC
abstract	MOTIVATION: Receptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered. RESULTS: Here, by manually curating a high-quality database of 268 pairs of mammalian virus–host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors are structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. This study could deepen our understanding of virus–receptor interaction. AVAILABILITY AND IMPLEMENTATION: The database of mammalian virus–host receptor interaction is available at http://www.computationalbiology.cn: 5000/viralReceptor. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
has issue date	2019-03-01(xsd:dateTime)
bibo:doi	10.1093/bioinformatics/bty694
bibo:pmid	30102334
has license	no-cc
sha1sum (hex)	e9316292ca1d7b6faf5b2f1d2a5f450d238a601b
schema:url	https://doi.org/10.1093/bioinformatics/bty694
resource representing a document's title	Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors
has PubMed Central identifier	PMC7109886
has PubMed identifier	30102334
schema:publication	Bioinformatics
resource representing a document's body	covid:e9316292ca1d7b6faf5b2f1d2a5f450d238a601b#body_text
is schema:about of	named entity 'HIGH' named entity 'N-GLYCOSYLATION' named entity 'HIGH EXPRESSION' named entity 'SUPPLEMENTARY INFORMATION' named entity 'PARTNERS' named entity 'PREFERRED' named entity 'MULTIPLE' named entity 'INTERACTION' named entity 'VIRUSES' named entity 'CELL MEMBRANE PROTEINS' named entity 'RECEPTORS' named entity 'MAMMALIAN' named entity 'N-glycosylation' named entity 'interaction partners' named entity 'plasma membrane' named entity 'cell membrane' named entity 'virus receptor' named entity 'amino acid' named entity 'homolog' named entity 'cytoplasmic' named entity 'Cytoscape' named entity 'gene' named entity 'database' named entity 'PPIs' named entity 'virus' named entity 'UniProt' named entity 'interaction partners' named entity 'mammal species' named entity 'database' named entity 'HMMER' named entity 'NCBI' named entity 'cell surface' named entity 'p-value' named entity 'Subcellular location' named entity 'HTR2A' named entity 'human tissues' named entity 'Expression Atlas' named entity 'mammal species' named entity 'mammal species' named entity 'UniProtKB' named entity 'virus' named entity 'cell membrane' named entity 'RefSeq' named entity 'amino acid' named entity 'alpha helix' named entity 'Viral myocarditis' named entity 'virus' named entity 'virus' named entity 'virus receptor' named entity 'protein' named entity '10.5' named entity 'viral species' named entity 'virus' named entity 'virus' named entity 'mammal species' named entity 'UniprotKB' named entity 'NCBI' named entity 'database' named entity 'protein sequences' named entity 'protein' named entity '10.5' named entity 'UniprotKB' named entity 'PPIs' named entity 'cytoplasm' named entity '3D structure' named entity 'cytoplasm' named entity 'database' named entity 'protein sequences'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software