About: Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens

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About: Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens
Creator	Althaus, Thomas Greer, R Turner, P Winchell, J Althaus, T Blacksell, ; Blacksell, S Day, N Diaz, M Dittrich, ; Dittrich, S Frcpath, P Lubell, Y Mrcgp, Greer Peerawaranun, ; Peerawaranun, P Prof, ; Smit, ; Smit, P Smithuis, F Swe Msc, M Swe, M Thaipadungpanit, ; Thaipadungpanit, J Wangrangsimakul, ; Wangrangsimakul, T
topic	covid:e8ac4d7d375a25793807c5c4f600319100efb483#this
Source	PMC
abstract	OBJECTIVES: We investigated causes of fever in the primary levels of care in Southeast Asia, and evaluated whether C-reactive protein (CRP) could distinguish bacterial from viral pathogens. METHODS: Blood and nasopharyngeal swab specimens were taken from children and adults with fever (>37.5˚C) or history of fever (<14 days) in Thailand and Myanmar. RESULTS: Of 773 patients with at least one blood or nasopharyngeal swab specimen collected, 227 (29.4%) had a target organism detected. Influenza virus type A was detected in 85/227 cases (37.5%), followed by dengue virus (30 cases, 13.2%), respiratory syncytial virus (24 cases, 10.6%) and Leptospira spp. (9 cases, 4.0%). Clinical outcome was similar between patients with a bacterial or a viral organism, regardless of antibiotic prescription. CRP was higher among patients with a bacterial organism compared to those with a viral organism (median 18 mg/L, interquartile range [10-49] versus 10 mg/L [≤8-22], p-value 0.003), with an area under the curve of 0.65, 95% confidence interval (0.55-0.75). CONCLUSIONS: Serious bacterial infections requiring antibiotics are exceptions rather than the rule in the first lines of care. CRP-testing could assist in ruling out such cases in settings where diagnostic uncertainty is high and routine antibiotic prescription is common. The original CRP randomised-controlled trial (RCT) was registered with ClinicalTrials.gov, number NCT02758821.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.05.016
has license	no-cc
sha1sum (hex)	e8ac4d7d375a25793807c5c4f600319100efb483
schema:url	https://doi.org/10.1016/j.ijid.2020.05.016
resource representing a document's title	Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens
has PubMed Central identifier	PMC7211754
schema:publication	Int J Infect Dis
resource representing a document's body	covid:e8ac4d7d375a25793807c5c4f600319100efb483#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/e8ac4d7d375a25793807c5c4f600319100efb483
is schema:about of	named entity 'BACTERIAL' named entity 'PRIMARY' named entity 'fever' named entity 'bacterial' named entity 'antibiotic' named entity 'infection' named entity 'CRP' named entity 'levels of care' named entity 'Southeast Asia' named entity 'dysentery' named entity 'Southeast Asia' named entity 'levels of care' named entity 'Myanmar' named entity 'vital signs' named entity 'diagnostic tests' named entity 'CRP' named entity 'dental abscess' named entity 'primary care' named entity 'control group' named entity 'clinical presentation' named entity 'paediatric' named entity 'infection' named entity 'viral DNA' named entity 'RSV' named entity 'primary care' named entity 'bacterial infections' named entity 'antibiotic' named entity 'influenza virus' named entity 'follow-up' named entity 'Africa' named entity 'antibiotic' named entity 'CRP' named entity 'POCT' named entity 'febrile illness' named entity 'febrile' named entity 'CRP' named entity 'CRP' named entity 'urinary tract infection' named entity 'antibiotics' named entity 'primary care' named entity 'bacteria' named entity 'azithromycin' named entity 'Southeast Asia' named entity 'biomarkers' named entity 'CRP' named entity 'Gastrointestinal syndrome' named entity 'malaria' named entity 'amoxicillin with clavulanic acid' named entity 'zoonoses' named entity 'Chiang Rai province' named entity 'CRP' named entity 'febrile illness' named entity 'chi-squared test' named entity 'Taqman' named entity 'Point-of-care diagnostic' named entity 'Antibiotics'

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