About: An infectious RNA with a hepta-adenosine stretch responsible for programmed −1 ribosomal frameshift derived from a full-length cDNA clone of Hibiscus latent Singapore virus

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About: An infectious RNA with a hepta-adenosine stretch responsible for programmed −1 ribosomal frameshift derived from a full-length cDNA clone of Hibiscus latent Singapore virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An infectious RNA with a hepta-adenosine stretch responsible for programmed −1 ribosomal frameshift derived from a full-length cDNA clone of Hibiscus latent Singapore virus
Creator	Wong, Sek-Man Cao, Shishu Niu, Shengniao
Source	Elsevier; Medline; PMC
abstract	Abstract Hibiscus latent Singapore virus (HLSV) is a member of Tobamovirus and its full-length cDNA clones were constructed. The in vitro transcripts from two HLSV full-length cDNA clones, which contain a hepta-adenosine stretch (pHLSV-7A) and an octo-adenosine stretch (pHLSV-8A), are both infectious. The replication level of HLSV-7A in Nicotiana benthamiana protoplasts was 5-fold lower, as compared to that of HLSV-8A. The replicase proteins of HLSV-7A were produced through programmed −1 ribosomal frameshift (−1 PRF) and the 7A stretch was a slippery sequence for −1 PRF. Mutations to the downstream pseudoknot of 7A stretch showed that the pseudoknot was not required for the frameshift in vitro. The stretch was found to be extended to 8A after subsequent replication cycles in vivo. It is envisaged that HLSV employs the monotonous runs of A and −1 PRF to convert its 7A to 8A to reach higher replication for its survival in plants.
has issue date	2014-01-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2013.11.021
bibo:pmid	24418557
has license	els-covid
sha1sum (hex)	e88181bbebba76f7480ee2627682f439935d3920
schema:url	https://doi.org/10.1016/j.virol.2013.11.021
resource representing a document's title	An infectious RNA with a hepta-adenosine stretch responsible for programmed −1 ribosomal frameshift derived from a full-length cDNA clone of Hibiscus latent Singapore virus
has PubMed Central identifier	PMC7127180
has PubMed identifier	24418557
schema:publication	Virology
resource representing a document's body	covid:e88181bbebba76f7480ee2627682f439935d3920#body_text
is schema:about of	named entity 'RIBOSOMAL FRAMESHIFT' named entity 'produced' named entity 'RESPONSIBLE' named entity 'INFECTIOUS' named entity 'LOWER' named entity 'TRANSCRIPTS' named entity 'NICOTIANA BENTHAMIANA' named entity 'EXTENDED' named entity 'SURVIVAL' named entity 'REACH' named entity 'CONSTRUCTED' named entity 'CONTAIN' named entity 'STRETCH' named entity 'SUBSEQUENT' named entity 'STRETCH' named entity 'ADENOSINE' named entity 'CDNA CLONE' named entity 'LENGTH' named entity 'PROTEINS' named entity 'REPLICASE' named entity 'IN VITRO' named entity 'NOT REQUIRED' named entity 'RUNS' named entity 'DERIVED' named entity 'SEQUENCE' named entity 'PRF' named entity 'CDNA' named entity 'WAS A' named entity 'LENGTH' named entity 'REPLICATION' named entity 'FRAMESHIFT' named entity 'HIBISCUS LATENT SINGAPORE VIRUS' named entity 'COMPARED' named entity 'HIBISCUS LATENT SINGAPORE VIRUS' named entity 'RNA' named entity 'INFECTIOUS' named entity 'TO CONVERT' named entity 'IN VIVO' named entity 'PSEUDOKNOT' named entity 'EMPLOYS' named entity 'LEVEL' named entity 'RIBOSOMAL FRAMESHIFT' named entity 'TOBAMOVIRUS' named entity 'MEMBER OF' named entity 'PLANTS' named entity 'ADENOSINE' named entity 'MUTATIONS' named entity 'PROTOPLASTS' named entity 'FOLD' named entity 'CLONES' named entity 'ITS' named entity 'HIGHER' named entity 'DOWNSTREAM' named entity 'IS A' named entity 'FOUND' covid:arg/e88181bbebba76f7480ee2627682f439935d3920 named entity 'Nicotiana benthamiana' named entity 'PRF' named entity 'convert' named entity 'ribosomal frameshift' named entity 'plants' named entity 'Singapore' named entity 'pseudoknot' named entity 'cDNA clones' named entity 'slippery sequence' named entity 'Singapore' named entity 'virus' named entity 'ribosomal frameshift' named entity 'frameshift' named entity 'adenosine' named entity 'Umbravirus' named entity 'replicases' named entity 'RNA elements' named entity 'replicase' named entity 'RNA' named entity 'transcription' named entity 'adenosine' named entity 'primers' named entity 'Life Technologies'

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