About: Papovavirus detection by electron microscopy in the brain of an elderly patient without overt progressive multifocal leukoencephalopathy

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About: Papovavirus detection by electron microscopy in the brain of an elderly patient without overt progressive multifocal leukoencephalopathy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Papovavirus detection by electron microscopy in the brain of an elderly patient without overt progressive multifocal leukoencephalopathy
Creator	Kato, K Mori, M Tajima, M Aoki, Naoto Aoki, • Kato, Kenzo Kouichi, • Mori, N Noda, K Shimada, H Shimada, Hiroyuki Tajima, Masako
Source	PMC
abstract	Virions resembling papovavirus were demonstrated in glial cells in the brain of an aged patient without overt progressive multifocal leukoencephalopathy. The patient was not in a severely immunocompromised state. On histological examination, only a few tiny incomplete necrotic foci were found in the subcortical area. These foci were widely dispersed. Rare, swollen oligodendroglial cells and astrocytes in which papovavirus capsid protein (VP-1) was demonstrated immunohistochemically were present around the foci. The two typical types of virus particles i.e. 35 to 40 nm round particles and elongated particles, were observed in the nuclei of the swollen glial cells. The latter were in the minority. Distinct crystals were also found in the nuclei. The centre-to-centre distance of the particles in the crystals, about 40 nm, and the electron-opaque spots of the round-shaped virions and of the elongated particles, were indicative of structural subunits of papovavirus capsids. This case provides further evidence that papovavirus, possibly JC virus, may be reactivated in the brains of aged patients who are not in an immunocompromised state.
has issue date	1994-01-01(xsd:dateTime)
bibo:doi	10.1007/bf00191445
bibo:pmid	8032537
has license	no-cc
sha1sum (hex)	e87cb83a9f9a7ab0dd40001bbe203e34f0319b4f
schema:url	https://doi.org/10.1007/bf00191445
resource representing a document's title	Papovavirus detection by electron microscopy in the brain of an elderly patient without overt progressive multifocal leukoencephalopathy
has PubMed Central identifier	PMC7087722
has PubMed identifier	8032537
schema:publication	Virchows Arch
resource representing a document's body	covid:e87cb83a9f9a7ab0dd40001bbe203e34f0319b4f#body_text
is schema:about of	named entity 'The' named entity 'FOCI' named entity 'OLIGODENDROGLIAL' named entity 'SPOTS' named entity 'ELONGATED' named entity 'indicative' named entity 'patient' named entity 'crystals' named entity 'JC virus' named entity 'immunocompromised' named entity 'immunohistochemically' named entity 'particles' named entity 'evidence' named entity 'typical' named entity 'virions' named entity 'necrotic' named entity 'nuclei' named entity 'astrocytes' named entity 'round-shaped' named entity 'immunocompromised state' named entity 'Papovavirus' named entity 'electron microscopy' named entity 'viruses' named entity 'papovavirus' named entity 'virions' named entity 'toluidine blue' named entity 'PML' named entity 'ethanol' named entity 'virions' named entity 'progressive multifocal leukoencephalopathy' named entity 'white matter' named entity 'virus' named entity 'immunocompetent' named entity 'cell-mediated' named entity 'virus' named entity 'macrophages' named entity 'polyclonal antibodies' named entity 'antigen' named entity 'PML' named entity 'remission' named entity 'immunostaining' named entity 'nuclear membrane' named entity 'virion' named entity 'pneumonia' named entity 'glial cells' named entity 'virions' named entity 'electron microscopy' named entity 'organelles' named entity 'dysarthria' named entity 'necrosis' named entity 'demyelination' named entity 'osmium tetroxide' named entity 'loci' named entity 'viral infection' named entity 'virus' named entity 'nuclei' named entity 'papovavirus' named entity 'lesion' named entity 'rhabdovirus' named entity 'papovaviruses' named entity 'necrotic' named entity 'histological examination' named entity 'stenosis' named entity 'blood pressure' named entity 'virus' named entity 'viruses' named entity 'transmission electron microscope' named entity 'GFAP' named entity 'PML' named entity 'brain stem'

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