About: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Abnormal regulation of TSG101 in mice with spongiform neurodegeneration
Creator	Bagher, Pooneh Cota, Christina Gunn, Teresa Jiao, Jian Sun, Kaihua Walker, Will
Source	Elsevier; Medline; PMC
abstract	Spongiform neurodegeneration is characterized by the appearance of vacuoles throughout the central nervous system. It has many potential causes, but the underlying cellular mechanisms are not well understood. Mice lacking the E3 ubiquitin ligase Mahogunin Ring Finger-1 (MGRN1) develop age-dependent spongiform encephalopathy. We identified an interaction between a “PSAP” motif in MGRN1 and the ubiquitin E2 variant (UEV) domain of TSG101, a component of the endosomal sorting complex required for transport I (ESCRT-I), and demonstrate that MGRN1 multimonoubiquitinates TSG101. We examined the in vivo consequences of loss of MGRN1 on TSG101 expression and function in the mouse brain. The pattern of TSG101 ubiquitination differed in the brains of wild-type mice and Mgrn1 null mutant mice: at 1 month of age, null mutant mice had less ubiquitinated TSG101, while in adults, mutant mice had more ubiquitinated, insoluble TSG101 than wild-type mice. There was an associated increase in epidermal growth factor receptor (EGFR) levels in mutant brains. These results suggest that loss of MGRN1 promotes ubiquitination of TSG101 by other E3s and may prevent its disassociation from endosomal membranes or cause it to form insoluble aggregates. Our data implicate loss of normal TSG101 function in endo-lysosomal trafficking in the pathogenesis of spongiform neurodegeneration in Mgrn1 null mutant mice.
has issue date	2009-10-01(xsd:dateTime)
bibo:doi	10.1016/j.bbadis.2009.08.009
bibo:pmid	19703557
has license	green-oa
sha1sum (hex)	e78ca38be8e94ab6738aec212d803f68e4e0a07e
schema:url	https://doi.org/10.1016/j.bbadis.2009.08.009
resource representing a document's title	Abnormal regulation of TSG101 in mice with spongiform neurodegeneration
has PubMed Central identifier	PMC2755232
has PubMed identifier	19703557
schema:publication	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
resource representing a document's body	covid:e78ca38be8e94ab6738aec212d803f68e4e0a07e#body_text
is schema:about of	named entity 'encephalopathy' named entity 'mice' named entity 'receptor' named entity 'mechanisms' named entity 'function' named entity 'mice' named entity 'E3 ubiquitin ligase' named entity 'ubiquitinated' named entity 'expression' named entity 'mice' named entity 'TSG101' named entity 'ITS' named entity 'ADULTS' named entity 'OUR' named entity 'MONTH' named entity 'MUTANT' named entity 'INTERACTION' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'THESE' named entity 'BUT' named entity 'CAUSE' named entity 'CAUSES' named entity 'TO FORM' named entity 'UBIQUITINATION' named entity 'TSG101' named entity 'ABNORMAL' named entity 'CONSEQUENCES' named entity 'ASSOCIATED' named entity 'DOMAIN' named entity 'COMPONENT' named entity 'CELLULAR' named entity 'BRAINS' named entity 'INSOLUBLE' named entity 'PREVENT' named entity 'NEURODEGENERATION' named entity 'AGGREGATES' named entity 'MEMBRANES' named entity 'TSG101' named entity 'PATHOGENESIS' named entity 'UBIQUITIN' named entity 'IDENTIFIED' named entity 'IN VIVO' named entity 'UBIQUITINATED' named entity 'APPEARANCE' named entity 'NORMAL' named entity 'FUNCTION' named entity 'MICE' named entity 'DEPENDENT' named entity 'EPIDERMAL GROWTH FACTOR RECEPTOR' named entity 'POTENTIAL' named entity 'VARIANT' named entity 'SUGGEST' named entity 'AGE' covid:arg/e78ca38be8e94ab6738aec212d803f68e4e0a07e named entity 'LACKING' named entity 'MOTIF' named entity 'NOT WELL' named entity 'PATTERN' named entity 'E3 UBIQUITIN LIGASE' named entity 'ENDO' named entity 'UNDERSTOOD' named entity 'NEURODEGENERATION' named entity 'MICE' named entity 'REGULATION' named entity 'EXAMINED' named entity 'MGRN1' named entity 'TRAFFICKING' named entity 'RING FINGER' named entity 'UNDERLYING' named entity 'RESULTS' named entity 'INCREASE' named entity 'MOUSE BRAIN' named entity 'NULL' named entity 'EXPRESSION' named entity 'DATA' named entity 'ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software