About: Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants
Creator	Vuorinen, Tytti Peltola, Ville Korhonen, Laura Lukkarinen, Minna Karlsson, Hasse Karlsson, Linnea Kortesluoma, Susanna Lukkarinen, Heikki Pelto, Juho Pesonen, Henri Tuulari, Jetro
Source	Elsevier; Medline; PMC
abstract	Abstract Introduction Prenatal exposure to maternal psychological distress (PD) may have programming effects on the fetus/infant hypothalamic-pituitary-adrenal (HPA) axis and subsequently on the development of the fetus’ immune function. Therefore, our aim was to study whether prenatal exposure to PD is related to early infant HPA axis reactivity in the context of a subclinical rhinovirus infection that challenges infants HPA axis postnatally. Methods This study included 336 10-week-old infants from the nested case control Focus Cohort of the FinnBrain Birth Cohort Study. The outcome was infant HPA axis reactivity in a stress test. The acute stressor comprised of pediatric examination with venipuncture and nasal swabs for virus assessment. Saliva cortisol samples were collected at 5 time points: baseline, 0, 15, 25 and 35 min after the stressor. HPA axis reactivity was defined by the cumulative post-stressor cortisol concentration. Results HPA axis reactivity was blunted in the PD/rhinovirus + group compared to the average of control/rhinovirus+, PD/rhinovirus-, and control/rhinovirus- groups (difference: 14.7 ln [nmol/L] × min, 95% confidence interval 3.8–25.6, p = .008). HPA axis reactivity was significantly blunted only in boys with rhinovirus detected when separately tested for boys and girls (p = .04). Conclusion Our finding of PD-exposed rhinovirus-positive infants having blunted cortisol secretion gives rise to a hypothesis that maternal PD during pregnancy influences infant HPA axis functioning and the functioning of the immune system. Future studies are needed to test whether this suppression of the HPA axis that co-occurs with rhinovirus infection associates with later disease development (e.g., asthma).
has issue date	2019-09-30(xsd:dateTime)
bibo:doi	10.1016/j.psyneuen.2019.05.023
bibo:pmid	31146139
has license	els-covid
sha1sum (hex)	e76561353698aad4b0b06c2672dcbc4b44e096c8
schema:url	https://doi.org/10.1016/j.psyneuen.2019.05.023
resource representing a document's title	Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants
has PubMed Central identifier	PMC7172058
has PubMed identifier	31146139
schema:publication	Psychoneuroendocrinology
resource representing a document's body	covid:e76561353698aad4b0b06c2672dcbc4b44e096c8#body_text
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