About: COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis

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About: COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis
Creator	Powell, Charles Chun, Glen Dangayach, Neha Kohli-Seth, Roopa Olin, Jeffrey Poor, Hooman Serrao, Gregory Tolbert, Thomas Ventetuolo, Corey Zeidman, Amanda
Source	Medline; PMC
abstract	Patients with severe COVID‐19 disease have been characterized as having the acute respiratory distress syndrome (ARDS). Critically ill COVID‐19 patients have relatively well‐preserved lung mechanics despite severe gas exchange abnormalities, a feature not consistent with classical ARDS but more consistent with pulmonary vascular disease. Many patients with severe COVID‐19 also demonstrate markedly abnormal coagulation, with elevated d‐dimers and higher rates of venous thromboembolism. We present four cases of patients with severe COVID‐19 pneumonia with severe respiratory failure and shock, with evidence of markedly elevated dead‐space ventilation who received tPA. All showed post treatment immediate improvements in gas exchange and/or hemodynamics. We suspect that severe COVID‐19 pneumonia causes respiratory failure via pulmonary microthrombi and endothelial dysfunction. Treatment for COVID‐19 pneumonia may warrant anticoagulation for milder cases and thrombolysis for more severe disease.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1002/ctm2.44
bibo:pmid	32508062
has license	cc-by
sha1sum (hex)	e75c7a85b8c543d9bf60a382e88ee5b26e5f2315
schema:url	https://doi.org/10.1002/ctm2.44
resource representing a document's title	COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis
has PubMed Central identifier	PMC7288983
has PubMed identifier	32508062
schema:publication	Clin Transl Med
resource representing a document's body	covid:e75c7a85b8c543d9bf60a382e88ee5b26e5f2315#body_text
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