About: Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19

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About: Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19
Creator	Li, Yuanyuan Dai, Yue Author, Corresponding Cheng, Ling Zuo, Peiyuan Zhang, Cuntai Chen, Yuting Gao, Hongyu Song, Kaixin Tong, Song Yan, Qi
Source	Elsevier; Medline; PMC
abstract	Objective: Severe patients tended to have lower serum prealbumin concentration in patients with novel coronavirus (SARS-CoV-2) infected pneumonia (COVID-19). This study was performed to investigate the association of prealbumin at baseline on COVID19-related mortality in elderly patients. Methods: We non-selectively and consecutively collected participants in Tongji Hospital in Wuhan from January 17 to February 17, 2020. Univariate and multivariate logistic regression models were employed to evaluate the correlation between prealbumin and in-hospital outcomes (in-hospital mortality, ICU admission and mechanical ventilation) in elderly COVID-19 patients. Linear trend was performed by entering the median value of each category of prealbumin tertile as continuous variable and was visually confirmed by using generalized additive models. Interaction and stratified analyses were conducted as well. Results: A total of 446 COVID-19 elderly patients were included in the final analyses and the in-hospital mortality was 14.79%. 15.47% patients admitted to intensive care unit and 21.3% patients required mechanical ventilation. Compared with patients in the highest tertile, the prealbumin of patients in the lowest tertile had a 19.09-fold higher risk of death (OR = 20.09; 95% CI, 3.62 to 111.64; P = 0.0006), 25.39-fold higher risk of ICU admission (OR = 26.39; 95% CI, 4.04to 172.39; P = 0.0006) and 1.8-fold higher risk of mechanical ventilation (OR = 2.8; 95% CI, 1.15 to 6.78; P = 0.0227) after adjustment for potential confounders. There was a linear trend correlation between serum prealbumin concentration and risk of in-hospital mortality, ICU admission and mechanical ventilation in elderly patients with COVID-19 infection. Conclusion: Prealbumin is an independent risk factor of the in-hospital mortality for COVID-19 elderly patients. Assessment of prealbumin may help identify high risk elderly individuals with COVID-19.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1016/j.nut.2020.110930
bibo:pmid	32854020
has license	no-cc
sha1sum (hex)	e2fca8b4b1b5b9416b5bf6caf30e74ad477fc241
schema:url	https://doi.org/10.1016/j.nut.2020.110930
resource representing a document's title	Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19
has PubMed Central identifier	PMC7333599
has PubMed identifier	32854020
schema:publication	Nutrition
resource representing a document's body	covid:e2fca8b4b1b5b9416b5bf6caf30e74ad477fc241#body_text
is schema:about of	named entity 'generalized' named entity 'risk' named entity 'evaluate' named entity 'infected' named entity 'ICU' named entity 'IDENTIFY' named entity 'HOSPITAL MORTALITY' named entity 'INCLUDED' named entity 'MORTALITY' named entity 'ELDERLY PATIENTS' named entity 'INTERACTION' named entity 'NUTRITION' named entity 'mortality' named entity 'infection' named entity 'models' named entity 'COVID-19' named entity 'fold' named entity '95% CI' named entity 'intensive care unit' named entity 'higher' named entity 'Conclusion' named entity 'elderly' named entity 'higher' named entity 'patients' named entity 'Interaction' named entity 'January 17' named entity 'visually' named entity '95% CI' named entity 'COVID' named entity 'Wuhan' named entity 'elderly individuals' named entity 'continuous variable' named entity 'mechanical ventilation' named entity 'higher risk' named entity 'risk factor' named entity 'linear trend' named entity 'mechanical ventilation' named entity 'Tongji Hospital' named entity 'prealbumin' named entity 'prealbumin' named entity 'elderly patients' named entity 'elderly patients' named entity 'ICU' named entity 'Nutrition' named entity 'mortality' named entity 'neutrophil' named entity 'confounding' named entity 'CKD' named entity 'prealbumin' named entity 'lymphocyte' named entity 'demographic data' named entity 'diagnostic criteria' named entity 'C-reactive protein' named entity 'immune function' named entity 'Declaration of Helsinki' named entity 'muscle mass' named entity 'tertile' named entity 'Boston, MA' named entity 'malnutrition' named entity 'coronary heart disease' named entity 'COVID-19' named entity 'lymphocyte' named entity 'regression analyses' named entity 'hypertension' named entity 'malnutrition' named entity 'prealbumin' named entity 'mechanical ventilation' named entity 'malnutrition' named entity 'lymphocyte count' named entity 'COVID-19' named entity 'fatigue'

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