About: Porcine epidemic diarrhea virus reduces feed efficiency in nursery pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine epidemic diarrhea virus reduces feed efficiency in nursery pigs
Creator	Schwartz, K Gabler, N Burrough, E Curry, S Lonergan, S Yoon, K
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) infects enterocytes and in nursery pigs, results in diarrhea, anorexia, and reduced performance. Therefore, the objective of this study was to determine how PEDV infection influenced growth performance and repartitioning of amino acids and energy in nursery pigs. A total of 32 barrows and gilts, approximately 1 wk post-wean (BW = 8.46 ± 0.50 kg), and naïve for PEDV were obtained, weighed, and allotted based on sex and BW to one of two treatments: 1) Control, PEDV naïve and 2) PEDV-inoculated (PEDV) with eight pens of two pigs each per treatment. On day post-inoculation (dpi) 0, PEDV pigs were inoculated via intragastric gavage with PEDV isolate (USA/Iowa/18984/2013). Pig and feeder weights were recorded at dpi −7, 0, 5, and 20 in order to calculate ADG, ADFI, and G:F. Eight pigs per treatment were euthanized on dpi 5 and 20, and tissues and blood were collected. At dpi 5, all PEDV pigs were PCR positive for PEDV in feces. Overall, PEDV pigs tended (P < 0.10) to increase ADFI, which resulted in reduced (P < 0.05) feed efficiency. At dpi 5, PEDV pigs had reduced (P < 0.05) villus height and increased (P < 0.05) stem cell proliferation in the jejunum compared with Control pigs. Pigs inoculated with PEDV had increased (P < 0.05) serum haptoglobin and increased insulin-to-glucose ratios compared with Control pigs at dpi 5. Markers of muscle proteolysis were not different (P > 0.05) between treatments within dpi; however, at dpi 5, 20S proteasome activity was increased (P < 0.05) in longissimus dorsi of PEDV pigs compared with Control pigs. Liver and jejunum gluconeogenic enzyme activities were not different (P > 0.05) between treatments within dpi. Overall, PEDV-inoculated pigs did recover the absorptive capacity that was reduced during PEDV infection by increasing proliferation of intestinal stem cells. However, the energy and nutrients needed to recover the epithelium may be originating from available luminal nutrients instead of muscle proteolysis and gluconeogenesis. This study provides insight into the effects of an enteric coronavirus on postabsorptive metabolism in nursery pigs.
has issue date	2018-01-01(xsd:dateTime)
bibo:doi	10.1093/jas/skx005
bibo:pmid	29378029
has license	bronze-oa
sha1sum (hex)	e21576322ef939295eb323666f7661d1e351ff5d
schema:url	https://doi.org/10.1093/jas/skx005
resource representing a document's title	Porcine epidemic diarrhea virus reduces feed efficiency in nursery pigs
has PubMed Central identifier	PMC6140930
has PubMed identifier	29378029
schema:publication	Journal of Animal Science
resource representing a document's body	covid:e21576322ef939295eb323666f7661d1e351ff5d#body_text
is schema:about of	named entity 'INCREASING' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MUSCLE' named entity 'ABSORPTIVE CAPACITY' named entity 'GLUCOSE' named entity 'PROLIFERATION' named entity 'COLLECTED' named entity 'RESULTS' named entity 'STEM CELL PROLIFERATION' named entity 'CONTROL' named entity 'INTESTINAL' named entity 'EFFECTS' named entity 'TREATMENTS' named entity 'BLOOD' named entity 'DPI' named entity 'ORDER' named entity 'HEIGHT' named entity 'TISSUES' named entity 'nutrients' named entity 'barrows' named entity 'proteolysis' named entity 'epithelium' named entity 'proteasome' named entity 'PIGS' named entity 'NURSERY' named entity 'PIGS' named entity 'OBJECTIVE' named entity 'PROTEOLYSIS' named entity 'PERFORMANCE' named entity 'DAY' named entity 'EUTHANIZED' named entity 'REDUCED' named entity 'LUMINAL' named entity 'ISOLATE' named entity 'MAY BE' named entity 'SERUM HAPTOGLOBIN' named entity '20S PROTEASOME' named entity 'PCR POSITIVE' named entity 'BASED' named entity 'LIVER' named entity 'TO CALCULATE' named entity 'POST' named entity 'ACTIVITIES' named entity 'AVAILABLE' named entity 'INCREASED' named entity '10%' named entity 'MARKERS' named entity 'ONE OF' named entity 'RATIOS' named entity 'ENZYME' named entity 'ENTERIC CORONAVIRUS' named entity '927' named entity 'GROWTH PERFORMANCE' named entity 'ANOREXIA' named entity 'NURSERY' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'COMPARED' named entity 'TO INCREASE' named entity 'HOW' named entity 'ENTEROCYTES' named entity 'GLUCONEOGENESIS' named entity 'BARROWS' named entity 'FEED EFFICIENCY' named entity 'NUTRIENTS' named entity 'INOCULATION' named entity 'INSIGHT' named entity 'DETERMINE' named entity 'APPROXIMATELY' named entity 'RECORDED' named entity 'GAVAGE' named entity 'POSITIVE FOR' named entity 'FECES' named entity 'DID' named entity 'NEEDED' named entity 'STEM CELLS' named entity 'GLUCONEOGENIC'

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