About: Regulation of influenza virus replication by Wnt/β-catenin signaling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of influenza virus replication by Wnt/β-catenin signaling
Creator	Yang, Xiaoyun Bailey, Keith Bamunuarachchi, Gayan Guo, Yujie Huang, Chaoqun Liu, Lin More, Sunil Zhu, Zhengyu Metcalf, Jordan
Source	Medline; PMC
abstract	Wnt/β-catenin signaling is an essential pathway in cell cycle control. Dysregulation of the Wnt/β-catenin signaling pathway during viral infection has been reported. In this study, we examined the effect of modulating Wnt/β-catenin signaling during influenza virus infection. The activation of the Wnt/β-catenin pathway by Wnt3a increased influenza virus mRNA and virus production in in vitro in mouse lung epithelial E10 cells and mRNA expresson of influenza virus genes in vivo in the lungs of mice infected with influenza virus A/Puerto Rico/8/34. However, the inhibition of Wnt/β-catenin signaling by iCRT14 reduced virus titer and viral gene expression in human lung epithelial A549 cells and viral replication in primary mouse alveolar epithelial cells infected with different influenza virus strains. Knockdown of β-catenin also reduced viral protein expression and virus production. iCRT14 acts at the early stage of virus replication. Treatment with iCRT14 inhibited the expression of the viral genes (vRNA, cRNA and mRNA) evaluated in this study. The intraperitoneal administration of iCRT14 reduced viral load, improved clinical signs, and partially protected mice from influenza virus infection.
has issue date	2018-01-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0191010
bibo:pmid	29324866
has license	cc-by
sha1sum (hex)	e209784c9a22ca29bf423b8d77359142db053182
schema:url	https://doi.org/10.1371/journal.pone.0191010
resource representing a document's title	Regulation of influenza virus replication by Wnt/β-catenin signaling
has PubMed Central identifier	PMC5764324
has PubMed identifier	29324866
schema:publication	PLoS One
resource representing a document's body	covid:e209784c9a22ca29bf423b8d77359142db053182#body_text
is schema:about of	named entity 'evaluated' named entity 'β-catenin' named entity 'signaling' named entity 'viral' named entity 'virus' named entity 'viral protein' named entity 'titer' named entity 'epithelial cells' named entity 'β-catenin' named entity 'mRNA' named entity 'INFECTED' named entity 'REPORTED' named entity 'A549 CELLS' named entity 'RICO' named entity 'VIRAL INFECTION' named entity 'INCREASED' named entity 'REGULATION' named entity 'WNT' named entity 'VIRUS PRODUCTION' named entity 'INFLUENZA VIRUS' named entity 'DIFFERENT' named entity 'EVALUATED' named entity 'MICE' named entity 'INTRAPERITONEAL ADMINISTRATION' named entity 'PRIMARY' named entity 'HUMAN LUNG' named entity 'TITER' named entity '2F8' named entity 'SIGNALING' named entity 'EXAMINED' named entity 'TREATMENT' named entity 'WNT' named entity 'CATENIN' named entity 'INFLUENZA VIRUS' named entity 'EARLY STAGE' named entity 'CELL CYCLE CONTROL' named entity 'VIRUS REPLICATION' named entity 'IN VITRO' named entity 'CATENIN' named entity 'REDUCED' named entity 'ALVEOLAR EPITHELIAL CELLS' named entity 'EPITHELIAL' named entity 'PROTEIN EXPRESSION' named entity 'PATHWAY' named entity 'EFFECT' named entity 'MRNA' named entity 'VIRUS' named entity 'ACTS' named entity 'THE LUNGS' named entity 'STUDY' named entity 'VIRAL GENE EXPRESSION' named entity 'INFLUENZA VIRUS A' named entity 'EXPRESSION' named entity 'WNT3A' named entity 'MOUSE LUNG' named entity 'STRAINS' named entity 'VIRAL GENES' named entity 'INHIBITION' named entity 'VIRAL LOAD' named entity 'SIGNALING PATHWAY' named entity 'E10' named entity 'CLINICAL SIGNS' named entity 'MODULATING' named entity 'ACTIVATION' named entity 'VIRAL PROTEIN' named entity 'IN VIVO' named entity 'GENES' named entity 'CRNA' named entity 'ESSENTIAL' named entity 'PARTIALLY' named entity 'VIRAL REPLICATION' named entity 'IMPROVED' named entity 'INHIBITED'

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