About: How the gut microbiome regulates host immune responses to viral vaccines

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	How the gut microbiome regulates host immune responses to viral vaccines
Creator	Miyazaki, Ayako Vlasova, Anastasia Rajashekara, Gireesh Saif, Linda Takanashi, Sayaka
Source	Elsevier; Medline; PMC
abstract	The co-evolution of the microbiota and immune system has forged a mutually beneficial relationship. This relationship allows the host to maintain the balance between active immunity to pathogens and vaccines and tolerance to self-antigens and food antigens. In children living in low-income and middle-income countries, undernourishment and repetitive gastrointestinal infections are associated with the failure of oral vaccines. Intestinal dysbiosis associated with these environmental influences, as well as some host-related factors, compromises immune responses and negatively impacts vaccine efficacy. To understand how immune responses to viral vaccines can be optimally modulated, mechanistic studies of the relationship between the microbiome, host genetics, viral infections and the development and function of the immune system are needed. We discuss the potential role of the microbiome in modulating vaccine responses in the context of a growing understanding of the relationship between the gastrointestinal microbiota, host related factors (including histo-blood group antigens) and resident immune cell populations.
has issue date	2019-08-01(xsd:dateTime)
bibo:doi	10.1016/j.coviro.2019.05.001
bibo:pmid	31163292
has license	cc-by
sha1sum (hex)	e1fadb50206234f3cc8bc1750506068f8597baa3
schema:url	https://doi.org/10.1016/j.coviro.2019.05.001
resource representing a document's title	How the gut microbiome regulates host immune responses to viral vaccines
has PubMed Central identifier	PMC6863389
has PubMed identifier	31163292
schema:publication	Curr Opin Virol
resource representing a document's body	covid:e1fadb50206234f3cc8bc1750506068f8597baa3#body_text
is schema:about of	named entity 'How' named entity 'commensal' named entity 'genetics' named entity 'pathogenic organisms' named entity 'mutually beneficial relationship' named entity 'vitamin' named entity 'lamina propria' named entity 'gastrointestinal microbiota' named entity 'systemic circulation' named entity 'TLR' named entity 'microbiome' named entity 'systemic inflammation' named entity 'vaccine' named entity 'antigens' named entity 'microbiota' named entity 'microbiome' named entity 'IgA' named entity 'ABO' named entity 'inflammation' named entity 'EED' named entity 'vaccination' named entity 'histo' named entity 'coevolved' named entity 'immune response' named entity 'immune responses' named entity 'probiotic' named entity 'vaccine' named entity 'polymorphisms' named entity 'microbiota' named entity 'pathogens' named entity 'mice' named entity 'homozygous' named entity 'Hepatitis B vaccine' named entity 'cytokine' named entity 'HBGA' named entity 'microbiota' named entity 'genetics' named entity 'type 1 diabetes' named entity 'synergistic' named entity 'zinc deficiency' named entity 'human cytomegalovirus' named entity 'gut microbiota' named entity 'intestinal microbiota' named entity 'topography' named entity 'parenterally' named entity 'TLR' named entity 'HBGA' named entity 'metabolites' named entity 'noroviruses' named entity 'parenteral' named entity 'genetics' named entity 'Helicobacter pylori' named entity 'causal relationships' named entity 'antimicrobial' named entity 'immunomodulatory' named entity 'HRV' named entity 'Mice' named entity 'Finland' named entity 'mucosal' named entity 'immune cells' named entity 'cellular signaling' named entity 'microbiota' named entity 'HRV' named entity 'microbiota' named entity 'hygiene' named entity 'intestine' named entity 'mRNA expression' named entity 'secretion' named entity 'histo' named entity 'MyD88' named entity 'SCFA' named entity 'antigen' named entity 'Zinc' named entity 'gut microbiota' named entity 'probiotic' named entity 'IgG' named entity 'immune function'

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