About: Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
Creator	Baranek, Thomas Dalod, Marc Zucchini, Nicolas
topic	covid:e1c4d9cdea7ddbf8cad8a101da840b3394c5303b#this
Source	PMC
abstract	Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease.
has issue date	2009-10-14(xsd:dateTime)
bibo:doi	10.3390/v1030383
bibo:pmid	21994554
has license	cc-by
sha1sum (hex)	e1c4d9cdea7ddbf8cad8a101da840b3394c5303b
schema:url	https://doi.org/10.3390/v1030383
resource representing a document's title	Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
has PubMed Central identifier	PMC3185500
has PubMed identifier	21994554
schema:publication	Viruses
resource representing a document's body	covid:e1c4d9cdea7ddbf8cad8a101da840b3394c5303b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/e1c4d9cdea7ddbf8cad8a101da840b3394c5303b
is schema:about of	named entity 'PHYSIOPATHOLOGY' named entity 'ANTIVIRAL' named entity 'HEALTH' named entity 'CYTOKINES' named entity 'PLAY' named entity 'IMMUNE RESPONSES' named entity 'HERE' named entity 'A MAJOR' named entity 'INTERFERONS' named entity 'EITHER' named entity 'TESTED' named entity 'VIRUSES' named entity 'INCLUDING' named entity 'pDC' named entity 'health' named entity 'professional' named entity 'detrimental' named entity 'herpesvirus' named entity 'potent' named entity 'HERPESVIRUS INFECTIONS' named entity 'PROMOTE' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'ESSENTIAL' named entity 'HOST' named entity 'HERPESVIRUS INFECTIONS' named entity 'ROLE' named entity 'IFN' named entity 'HERPESVIRUSES' named entity 'ACTIVATION' named entity 'TYPE' named entity 'ACTIVITIES' named entity 'EVIDENCE' named entity 'VERTEBRATE' named entity 'DEFENSE' named entity 'INITIAL' named entity 'CONTROL' named entity 'DENDRITIC CELLS' named entity 'PDCS' named entity 'PRODUCERS' named entity 'DISCUSS' named entity 'DISEASE' named entity 'DENDRITIC CELLS' named entity 'PDC' named entity 'KNOWLEDGE' named entity 'SETTINGS' named entity 'MOUSE' named entity 'MAY BE' named entity 'PLASMACYTOID' named entity 'PATTERN' named entity 'PROFESSIONAL' named entity 'PLASMACYTOID' named entity 'THEIR' named entity 'FUNCTIONS' named entity 'RESPONSES' named entity 'CURRENT' named entity 'DIRECT' named entity 'HUMAN HERPESVIRUS' named entity 'MULTIPLICITY' named entity 'RESPONSE TO' named entity 'MEDIATE' named entity 'HOW' named entity 'HAVE' named entity 'ADAPTIVE' named entity 'STRONG' named entity 'disease' named entity 'functions' named entity 'antiviral' named entity 'viruses' named entity 'direct' named entity 'pDCs' named entity 'functions' named entity 'strong' named entity 'immunotherapeutic' named entity 'herpesviruses' named entity 'antiviral' named entity 'human herpesvirus' named entity 'physiopathology'

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