About: Early use of beta-blockers attenuates systemic inflammatory response and lung oxygenation impairment after distal type acute aortic dissection

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About: Early use of beta-blockers attenuates systemic inflammatory response and lung oxygenation impairment after distal type acute aortic dissection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Early use of beta-blockers attenuates systemic inflammatory response and lung oxygenation impairment after distal type acute aortic dissection
Creator	Anzai, Toshihisa Anzai, · Jo, Y Jo, Yusuke Kohno, Takashi Kohno, · Naito, Kotaro Naito, · Ogawa, Satoshi Ogawa, · Sugano, Y Sugano, Yasuo Ueno, Koji Ueno, · Yoshikawa, Tsutomu Yoshikawa, ·
source	PMC
abstract	We have reported that serum C-reactive protein (CRP) elevation is an independent predictor of lung oxygenation impairment (LOI) after distal type acute aortic dissection (AAD). Systemic activation of the inflammatory system after aortic injury may play a role in the development of LOI. The aim of this study is to clarify the effect of beta-blockers on systemic inflammation and the development of LOI after distal type AAD. A total of 49 patients, who were admitted with distal type AAD and treated conservatively, were examined. White blood cell (WBC) count, serum CRP level, and arterial blood gases were measured serially. Forty patients received beta-blocker treatment within 24 h of the onset, while 9 patients received no beta-blocker treatment. Maximum WBC count, maximum CRP level, lowest PaO(2)/FiO(2) (P/F) ratio, and patient background were compared between the two groups. There was no difference between the groups according to age, sex, coronary risk factors, blood pressure, serum level of CRP, WBC count, and oxygenation index on admission. Beta-blocker treatment was associated with lower maximum WBC count (P = 0.0028) and lower maximum serum CRP level (P = 0.0004). The minimum P/F ratio was higher in patients with beta-blocker treatment than in those without (P = 0.0076). Multivariate analysis revealed that administration of a beta-blocker was an independent negative determinant of LOI (P/F ratio ≤200 mmHg). In conclusion, early use of beta-blockers prevented excessive inflammation and LOI after distal type AAD, suggesting a pleiotropic effect of beta-blockers on the inflammatory response after AAD.
has issue date	2008-09-20(xsd:dateTime)
bibo:doi	10.1007/s00380-008-1048-7
bibo:pmid	18810582
has license	no-cc
sha1sum (hex)	e135ced2effa0828634a4070e3fff0964fddffe0
schema:url	https://doi.org/10.1007/s00380-008-1048-7
resource representing a document's title	Early use of beta-blockers attenuates systemic inflammatory response and lung oxygenation impairment after distal type acute aortic dissection
has PubMed Central identifier	PMC7101827
has PubMed identifier	18810582
schema:publication	Heart Vessels
resource representing a document's body	covid:e135ced2effa0828634a4070e3fff0964fddffe0#body_text
is schema:about of	named entity 'oxygenation' named entity 'coronary' named entity 'systemic' named entity 'distal' named entity 'distal' named entity 'HIGHER' named entity 'AORTIC INJURY' named entity 'COMPARED' named entity 'ABSTRACT' named entity 'MEASURED' named entity 'WBC COUNT' named entity 'PAO' named entity 'SERUM CRP' named entity 'EXCESSIVE' named entity 'count' named entity 'AAD' named entity 'activation' named entity 'Forty' named entity 'AAD' named entity 'clarify' named entity 'count' named entity 'morbidity' named entity 'systolic pressure' named entity 'pleiotropic' named entity 'Multivariate analysis' named entity 'betablocker' named entity 'distal' named entity 'beta-blockers' named entity 'risk factors' named entity 'determinant' named entity 'infl' named entity 'onset' named entity 'infl' named entity 'infl' named entity 'development' named entity 'WBC' named entity 'distal' named entity 'WBC' named entity 'blood pressure' named entity 'distal' named entity 'beta-blocker' named entity 'serum' named entity 'C-reactive protein' named entity 'pleiotropic' named entity 'White blood cell' named entity 'CRP' named entity 'betablocker' named entity 'CRP' named entity 'aortic dissection' named entity 'beta-blockers' named entity 'automated hematology' named entity 'blood gas' named entity 'reactive oxygen' named entity 'angiotensin II receptor blockers' named entity 'abdominal aorta' named entity 'CRP' named entity 'antioxidant' named entity 'TNF-α' named entity 'neutrophils' named entity 'beta-blocker' named entity 'WBC' named entity 'WBC' named entity 'CRP' named entity 'CRP' named entity 'troponin' named entity 'bioavailability'

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