About: Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia

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About: Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia
Creator	Carriche, Guilhermina Castro, \| Lobo-Silva, Diogo Roque, Susana Saraiva, Margarida
Source	Medline; PMC
abstract	Pattern recognition receptors, such as toll‐like receptors (TLRs), perceive tissue alterations and initiate local innate immune responses. Microglia, the resident macrophages of the brain, encode TLRs which primary role is to protect the tissue integrity. However, deregulated activation of TLRs in microglia may lead to chronic neurodegeneration. This double role of microglial responses is often reported in immune‐driven neurologic diseases, as in multiple sclerosis (MS). Consequently, strategies to manipulate microglia inflammatory responses may help to ameliorate disease progression. In this context, the anti‐inflammatory cytokine interleukin (IL)‐10 appears as an attractive target. In this study, we investigated how activation of microglia by TLRs with distinct roles in MS impacts on IL‐10 production. We found that activation of TLR2, TLR4, and TLR9 induced the production of IL‐10 to a greater extent than activation of TLR3. This was surprising as both TLR3 and IL‐10 play protective roles in animal models of MS. Interestingly, combination of TLR3 triggering with the other TLRs, enhanced IL‐10 through the modulation of its transcription, via interferon (IFN)‐β, but independently of IL‐27. Thus, in addition to the modulation of inflammatory responses of the periphery described for the axis TLR3/IFN‐β, we now report a direct modulation of microglial responses. We further show that the presence of IFN‐γ in the microenvironment abrogated the modulation of IL‐10 by TLR3, whereas that of IL‐17 had no effect. Considering the therapeutic application of IFN‐β in MS, our study bears important implications for the understanding of the cytokine network regulating microglia responses in this setting.
has issue date	2017-06-15(xsd:dateTime)
bibo:doi	10.1002/glia.23172
bibo:pmid	28617991
has license	no-cc
sha1sum (hex)	e04c4d763a6607a21e7042026ed11652c20af066
schema:url	https://doi.org/10.1002/glia.23172
resource representing a document's title	Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia
has PubMed Central identifier	PMC7165667
has PubMed identifier	28617991
schema:publication	Glia
resource representing a document's body	covid:e04c4d763a6607a21e7042026ed11652c20af066#body_text
is schema:about of	named entity 'Pattern recognition' named entity 'Thus' named entity 'study' named entity 'TLRs' named entity 'interleukin' named entity 'microglia' named entity 'NEURODEGENERATION' named entity 'MULTIPLE SCLEROSIS' named entity 'IMMUNE RESPONSES' named entity 'PERCEIVE' named entity 'TRANSCRIPTION' named entity 'activation' named entity 'abrogated' named entity 'triggering' named entity 'modulation' named entity 'responses' named entity 'TLR3' named entity 'periphery' named entity 'TLR3' named entity 'IL-10' named entity 'This' named entity 'TLR3' named entity 'IL-10' named entity 'modulation' named entity 'microglia' named entity 'interleukin (IL)-10' named entity 'IFN' named entity 'TLR4' named entity 'IFN' named entity 'IL-27' named entity 'TLR3' named entity 'IL-10' named entity 'TLR2' named entity 'cytokine' named entity 'TLRs' named entity 'microenvironment' named entity 'anti-inflammatory' named entity 'TLRs' named entity 'neurologic diseases' named entity 'Pattern recognition receptors' named entity 'TLR3' named entity 'Microglia' named entity 'macrophages' named entity 'toll-like receptor' named entity 'double role' named entity 'target' named entity 'IL-10' named entity 'Bonifati' named entity 'microglial cells' named entity 'microglia' named entity 'EAE' named entity 'microglia' named entity 'cytokines' named entity 'transcription factors' named entity 'tissue damage' named entity 'innate immune responses' named entity 'IFN' named entity 'microglia' named entity 'IFNAR' named entity 'microglia' named entity 'mRNA' named entity 'LPS' named entity 'IL-10' named entity 'type I IFN' named entity 'TLR' named entity 'myeloid' named entity 'gene' named entity 'cell cultures' named entity 'mouse hepatitis virus' named entity 'transcription' named entity 'IL-10' named entity 'microglial cells' named entity 'secretion' named entity 'TLR2' named entity 'mRNA' named entity 'TLR2' named entity 'molecule'

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