About: Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

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About: Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
Creator	Chen, Gang Frieman, Matthew Weston, Stuart Zhou, Yi Babb, Robert Fairhurst, Jeanette Olson, William Rafique, Ashique Stahl, Neil Yan, Ying Baum, Alina Sivapalasingam, Sumathi Logue, James Chen, Calvin Chien Lye, David Huang, Tammy Kyratsous, Christos Pascal, Kristen Chung, Kyung Bouffard, Pascal Cheng, Jemmie Cruz, Jonathan Deshpande, Dipali Farr, Glen Franklin, Matthew Fulton, Benjamin Giordano, Stephanie Hansen, Johanna Haupt, Robert Hermann, Aynur Koon, Katrina Lee, Wen-Yi Levenkova, Natasha Libertiny, Christen Malbec, Marine Murphy, Andrew Patel, Krunal Pennington, Seth Romero Hernandez, Annabel Russo, Vincenzo Saotome, Kei Ullman, Erica Watty, Anke Welsh, Richard Wloga, Elzbieta Yancopoulos, George Zhang, Bojie
Source	Medline; PMC
abstract	Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola – one from genetically-humanized mice, and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the SARS-CoV-2 spike protein, yielding a large collection of fully-human antibodies that were characterized for binding, neutralization and three dimensional structure. Based on these criteria, we selected pairs of highly-potent individual antibodies that simultaneously bind the receptor-binding domain of the spike protein, providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single antibody treatment.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1126/science.abd0827
bibo:pmid	32540901
has license	cc-by
sha1sum (hex)	dfe7ad38785c53965d157278a4f2f0bad7e3368f
schema:url	https://doi.org/10.1126/science.abd0827
resource representing a document's title	Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
has PubMed Central identifier	PMC7299284
has PubMed identifier	32540901
schema:publication	Science
resource representing a document's body	covid:dfe7ad38785c53965d157278a4f2f0bad7e3368f#body_text
is schema:about of	named entity 'antibodies' named entity 'ACE2' named entity 'monomeric' named entity 'RBD' named entity '10.6' named entity 'protein binding' named entity 'antibodies' named entity 'antibodies' named entity 'asthma' named entity 'Fab fragments' named entity 'VH2' named entity 'cell types' named entity 'SARS-CoV-2' named entity 'antibodies' named entity 'antibodies' named entity 'virus' named entity 'mAbs' named entity 'Spleens' named entity 'pseudotyped' named entity 'SARS-CoV-2' named entity 'antibodies' named entity 'protease' named entity 'virus' named entity 'RBD' named entity 'Fab region' named entity 'SARS-CoV-2' named entity 'mAbs' named entity 'mAbs' named entity 'antibodies' named entity 'IgG' named entity 'mAbs' named entity 'IgG' named entity 'potency' named entity 'RBD' named entity 'non-infectious disease'

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