About: Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28

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About: Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28
Creator	Liu, Jie Li, Chen Cheng, Linyue Lu, Yongzhong Qiu, Qian
Source	Elsevier; Medline; PMC
abstract	Since effective chemotherapeutics or preventive measures are still unavailable, finding feasible approaches against white spot syndrome virus (WSSV) has always been the vital subject in shrimp farming field. Envelope proteins are the ideal targets for antiviral strategies development due to their indispensable roles in virus entry, and inhibitory peptides targeting them have been proved to be promising in blocking virus infection. In this study, the Wimley-White interfacial hydrophobicity scale (WWIHS) in combination with known structural data was applied to identify potential inhibitory peptides that targeted the envelope protein VP28 of WSSV. Results showed that two potential inhibitory peptides were identified, one of which exhibited not only obvious antiviral activity, but also broad-spectrum antimicrobial activity. The inhibitory peptide identified here can serve as a lead compound for anti-WSSV strategies development.
has issue date	2019-04-15(xsd:dateTime)
bibo:doi	10.1016/j.aqrep.2019.100195
bibo:pmid	32289063
has license	no-cc
sha1sum (hex)	dfa5e9afb8cea314d0f18deaaae441dd7106c5cb
schema:url	https://doi.org/10.1016/j.aqrep.2019.100195
resource representing a document's title	Computational identification of self-inhibitory peptides from white spot syndrome virus envelope protein VP28
has PubMed Central identifier	PMC7104047
has PubMed identifier	32289063
schema:publication	Aquac Rep
resource representing a document's body	covid:dfa5e9afb8cea314d0f18deaaae441dd7106c5cb#body_text
is schema:about of	named entity 'KNOWN' named entity 'APPROACHES' named entity 'ROLES' named entity 'INDISPENSABLE' named entity 'ENVELOPE' named entity 'HAVE' named entity 'VIRUS INFECTION' named entity 'PREVENTIVE' named entity 'SUBJECT' named entity 'SCALE' named entity 'LEAD COMPOUND' named entity 'IDENTIFIED' named entity 'TARGETS' named entity 'WHITE SPOT SYNDROME VIRUS' named entity 'FINDING' named entity 'PROTEIN ' named entity 'activity' named entity 'field' named entity 'development' named entity 'obvious' named entity 'PROTEIN ' named entity 'VIRUS ENVELOPE' named entity 'IDENTIFICATION' named entity 'ANTIVIRAL ACTIVITY' named entity 'IDEAL' named entity 'ANTIVIRAL' named entity 'HYDROPHOBICITY' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'SELF' named entity 'WHITE SPOT SYNDROME VIRUS' named entity 'STUDY' named entity 'SERVE' named entity 'TARGETED' named entity 'THEIR' named entity 'UNAVAILABLE' named entity 'CHEMOTHERAPEUTICS' named entity 'VITAL' named entity 'WSSV' named entity 'APPLIED' named entity 'PEPTIDES' named entity 'COMPUTATIONAL' named entity 'INHIBITORY' named entity 'DEVELOPMENT' named entity 'VIRUS ENTRY' named entity 'FEASIBLE' named entity 'SPECTRUM' named entity 'HERE' named entity 'PROTEINS' named entity 'INHIBITORY' named entity 'ONE OF' named entity 'STRATEGIES' named entity 'BLOCKING' named entity 'WHITE' named entity 'POTENTIAL' named entity 'COMBINATION' named entity 'ENVELOPE PROTEIN' named entity 'DUE TO' named entity 'ENVELOPE PROTEIN' named entity 'EFFECTIVE' named entity 'RESULTS' named entity 'MEASURES' named entity 'PEPTIDES' named entity 'TO IDENTIFY' named entity 'SHRIMP FARMING' named entity 'PEPTIDE' named entity 'BROAD' named entity 'BUT' named entity 'FIELD' named entity 'TARGETING' named entity 'STRUCTURAL DATA' covid:arg/dfa5e9afb8cea314d0f18deaaae441dd7106c5cb named entity 'strategies' named entity 'protein' named entity 'WSSV' named entity 'data' named entity 'development' named entity 'inhibitory'

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