About: Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014

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About: Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014
Creator	Piralla, Antonio Jin, Dong-Yan Tagliabue, Claudia Bianchini, Sonia Esposito, Susanna Principi, Nicola Mori, Alessandro Scala, Alessia Fossali, Emilio Zampiero, Alberto Sciarrabba, Calogero
Source	Medline; PMC
abstract	To evaluate the predominant human adenovirus (HAdV) species and types associated with pediatric respiratory infections, nasopharyngeal swabs were collected from otherwise healthy children attending an emergency room in Milan, Italy, due to a respiratory tract infection from January 1 to February 28 of two subsequent years, 2013 and 2014. The HAdVs were detected using a respiratory virus panel fast assay (xTAG RVP FAST v2) and with a HAdV-specific real-time polymerase chain reaction; their nucleotides were sequenced, and they were tested for positive selection. Among 307 nasopharyngeal samples, 61 (19.9%) tested positive for HAdV. HAdV was the only virus detected in 31/61 (50.8%) cases, whereas it was found in association with one other virus in 25 (41.0%) cases and with two or more viruses in 5 (8.2%) cases. Human Enterovirus/human rhinovirus and respiratory syncytial virus were the most common co-infecting viral agents and were found in 12 (19.7%) and 7 (11.5%) samples, respectively. Overall, the HAdV strain sequences analyzed were highly conserved. In comparison to HAdV-negative children, those infected with HAdV had a reduced frequency of lower respiratory tract involvement (36.1% vs 55.2%; p = 0.007), wheezing (0.0% vs 12.5%; p = 0.004), and hospitalization (27.9% vs 56.1%; p<0.001). Antibiotic therapy and white blood cell counts were more frequently prescribed (91.9% vs 57.1%; p = 0.04) and higher (17,244 ± 7,737 vs 9,565 ± 3,211 cells/μL; p = 0.04), respectively, in children infected by HAdV-C than among those infected by HAdV-B. On the contrary, those infected by HAdV-B had more frequently lower respiratory tract involvement (57.1% vs 29.7%) but difference did not reach statistical significant (p = 0.21). Children with high viral load were absent from child care attendance for a longer period of time (14.5 ± 7.5 vs 5.5 ± 3.2 days; p = 0.002) and had higher C reactive protein levels (41.3 ± 78.5 vs 5.4 ± 9.6 μg/dL; p = 0.03). This study has shown that HAdV infections are diagnosed more commonly than usually thought and that HAdVs are stable infectious agents that do not frequently cause severe diseases. A trend toward more complex disease in cases due to HAdV species C and in those with higher viral load was demonstrated. However, further studies are needed to clarify factors contributing to disease severity to understand how to develop adequate preventive and therapeutic measures.
has issue date	2016-04-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0152375
bibo:pmid	27045588
has license	cc-by
sha1sum (hex)	ddc5f3a230c72bfbbbd1b0235b21ae8d8ad4221e
schema:url	https://doi.org/10.1371/journal.pone.0152375
resource representing a document's title	Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014
has PubMed Central identifier	PMC4821614
has PubMed identifier	27045588
schema:publication	PLoS One
resource representing a document's body	covid:ddc5f3a230c72bfbbbd1b0235b21ae8d8ad4221e#body_text
is schema:about of	named entity 'counts' named entity 'Antibiotic' named entity 'child care' named entity 'high' named entity 'μg/dL' named entity 'positive selection' named entity 'strain' named entity 'Enterovirus' named entity 'Italy' named entity 'detected' named entity 'therapy' named entity 'predominant' named entity 'samples' named entity 'HOSPITALIZATION' named entity 'BLOOD CELL COUNTS' named entity 'BCL' named entity 'TYPES' named entity 'PRESCRIBED' named entity 'ASSOCIATED WITH' named entity 'PERIOD OF TIME' named entity 'DIFFERENCE' named entity 'DO NOT' named entity 'PREDOMINANT' named entity 'VIRAL LOAD' named entity 'FAST' named entity 'JANUARY' named entity 'ABSENT' named entity 'SAMPLES' named entity 'INFECTING' named entity 'WHEEZING' covid:arg/ddc5f3a230c72bfbbbd1b0235b21ae8d8ad4221e named entity 'infections' named entity 'nasopharyngeal' named entity 'February 28' named entity 'fast' named entity 'cases' named entity 'reduced' named entity 'wheezing' named entity 'detected' named entity 'Italy' named entity 'samples' named entity 'January' named entity 'Human' named entity 'hospitalization' named entity 'Adenovirus' named entity 'sequenced' named entity 'real-time polymerase chain reaction' named entity 'emergency room' named entity 'lower respiratory tract' named entity 'highly conserved' named entity '7.5' named entity 'virus' named entity 'Milan' named entity 'lower respiratory tract' named entity 'Respiratory Infections' named entity 'PCR' named entity 'infectious agent' named entity 'Ca' Granda' named entity 'Sequencher' named entity 'RSV' named entity 'early spring' named entity 'plasmid' named entity 'sequence assembly' named entity 'primers' named entity 'pediatric' named entity 'PCR' named entity 'CRP' named entity 'Applied Biosystems' named entity 'CAP' named entity 'fever' named entity 'infection'

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