About: Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy

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About: Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy
Creator	Lorusso, Alessio Tinelli, Antonella Marcacci, Maurilia Savini, Giovanni Berjaoui, Shadia Boari, Andrea Cito, Francesca De Luca, Eliana Di Teodoro, Giovanni Dondi, Francesco Malatesta, Daniela Puglia, Ilaria Ripà, Paola Vincifori, Giacomo Colaianni, Maria D'alterio, Nicola Crisi, Paolo Sabatino, Daria
source	Elsevier; Medline; PMC
abstract	Abstract Feline morbillivirus (FeMV) is an emerging morbillivirus first described in cats less than a decade ago. FeMV has been associated with chronic kidney disease of cats characterized by tubulointerstitial nephritis (TIN), although this aspect is still controversial and not demonstrated with certainty. To investigate FeMV prevalence and genomic characteristics, an epidemiological survey was conducted in a total number of 127 household cats originating from two Italian regions, Abruzzi and Emilia-Romagna. A total number of 69 cats originating from three feline colonies were also enrolled for the study. Correlation with TIN was investigated by employing a total number of 35 carcasses. Prevalence of FeMV RNA was higher in urine samples collected from cats of colonies (P = 31.8%, CI 95% 22.1–43.6) compared to household cats (P = 8.66%, CI 95% 4.9–14.9) and in young and middle-aged cats while prevalence of FeMV Abs was higher in old cats. Sequences obtained straight from infected biological samples, either partial or complete, cluster into two clades within FeMV genotype 1, distantly related to FeMV genotype 2. Immunohistochemistry analysis of kidney sections of FeMV RNA positive cats revealed immunoreactivity within epithelial cells of renal tubuli and inflammatory cells. However, statistically significant association between FeMV and renal damages, including TIN, was not demonstrated (p= 0.0695, Fisher exact test). By virus histochemistry performed with FeMV-negative feline tissues and a FeMV isolate, tropism for different cellular types such as inflammatory cells residing in blood vessels of kidney and brain, airway epithelial cells, alveolar macrophages and to a lesser extent, the central nervous system, was demonstrated. Additional studies are warranted in order to establish viral tropism and immune response during the early phases of infection and to disentangle the role of FeMV in co-infection processes.
has issue date	2020-01-31(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.108484
bibo:pmid	31902482
has license	els-covid
sha1sum (hex)	ddbe321178b25ba2cc1f1f9b3a3e87a8724f2380
schema:url	https://doi.org/10.1016/j.vetmic.2019.108484
resource representing a document's title	Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy
has PubMed Central identifier	PMC7127367
has PubMed identifier	31902482
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:ddbe321178b25ba2cc1f1f9b3a3e87a8724f2380#body_text
is schema:about of	named entity 'morbillivirus' named entity 'order' named entity 'histochemistry' named entity 'higher' named entity 'cats' named entity 'demonstrated' named entity 'aspects' named entity 'EARLY' named entity 'EITHER' named entity 'COMPARED' named entity 'HISTOCHEMISTRY' named entity 'ROLE' named entity 'MORBILLIVIRUS' named entity 'NUMBER OF' named entity 'COLONIES' named entity 'EPIDEMIOLOGICAL SURVEY' named entity 'CARCASSES' named entity 'TOTAL NUMBER' named entity 'CHRONIC KIDNEY DISEASE' named entity 'ASSOCIATION' named entity 'KIDNEY' named entity 'ASPECT' named entity 'LESS THAN' named entity 'HIGHER' named entity 'PREVALENCE' named entity 'INVESTIGATED' named entity 'STUDY' named entity 'VIRUS' named entity 'RELATED' named entity 'MIDDLE' named entity 'CORRELATION' named entity '28P' named entity 'NEGATIVE' named entity 'INFLAMMATORY CELLS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'EXACT TEST' named entity 'REVEALED' named entity 'CHARACTERIZED' named entity 'OLD' named entity 'CATS' named entity 'PERFORMED' named entity 'ANALYSIS' named entity 'TIN' named entity 'INFECTED' named entity 'COMPLETE' named entity 'EXTENT' named entity 'HETEROGENEITY' named entity 'ITALIAN' named entity 'ESTABLISH' named entity 'NOT DEMONSTRATED' named entity 'GENOME' named entity 'YOUNG' named entity 'TO INVESTIGATE' named entity 'ALVEOLAR MACROPHAGES' named entity 'OBTAINED' named entity 'FELINE MORBILLIVIRUS' named entity 'IMMUNOREACTIVITY' named entity 'FISHER' named entity 'FELINE' named entity 'AGED' named entity 'STUDIES' named entity 'ISOLATE' named entity 'CELLULAR TYPES' named entity 'COLLECTED'

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