About: Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2

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About: Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2
Creator	Gojobori, Takashi Alam, Intikhab Duarte, Carlos Teresa Sanchez-Aparicio, Maria Arold, Stefan Kamau, Allan Kulmanov, Maxat Pain, Arnab Jaremko, Łukasz Bhaduri-Mcintosh, Sumita Valenzuela-Fernandez, Agustin
Source	Medline; PMC
abstract	The spread of the novel coronavirus (SARS-CoV-2) has triggered a global emergency, that demands urgent solutions for detection and therapy to prevent escalating health, social, and economic impacts. The spike protein (S) of this virus enables binding to the human receptor ACE2, and hence presents a prime target for vaccines preventing viral entry into host cells. The S proteins from SARS and SARS-CoV-2 are similar, but structural differences in the receptor binding domain (RBD) preclude the use of SARS-specific neutralizing antibodies to inhibit SARS-CoV-2. Here we used comparative pangenomic analysis of all sequenced reference Betacoronaviruses, complemented with functional and structural analyses. This analysis reveals that, among all core gene clusters present in these viruses, the envelope protein E shows a variant cluster shared by SARS and SARS-CoV-2 with two completely-conserved key functional features, namely an ion-channel, and a PDZ-binding motif (PBM). These features play a key role in the activation of the inflammasome causing the acute respiratory distress syndrome, the leading cause of death in SARS and SARS-CoV-2 infections. Together with functional pangenomic analysis, mutation tracking, and previous evidence, on E protein as a determinant of pathogenicity in SARS, we suggest E protein as an alternative therapeutic target to be considered for further studies to reduce complications of SARS-CoV-2 infections in COVID-19.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.3389/fcimb.2020.00405
bibo:pmid	32850499
has license	cc-by
sha1sum (hex)	dd3e592803ce296480a0264145cca44ba5254a52
schema:url	https://doi.org/10.3389/fcimb.2020.00405
resource representing a document's title	Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2
has PubMed Central identifier	PMC7396417
has PubMed identifier	32850499
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:dd3e592803ce296480a0264145cca44ba5254a52#body_text
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