About: Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic
Creator	Lazcano, Antonio Jácome, Rodrigo Ponce De León, Samuel Alberto Campillo-Balderas, José Becerra, Arturo
Source	Medline; PMC
abstract	As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside analog antiviral approved for hepatitis C virus infections, with the SARS-CoV polymerase shows that the residues that bind to the drug are present in the latter. Moreover, a multiple alignment of several SARS-CoV-2, SARS and MERS-related coronaviruses polymerases shows that these residues are conserved in all these viruses, opening the possibility to use sofosbuvir against these highly infectious pathogens.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1038/s41598-020-66440-9
bibo:pmid	32518317
has license	cc-by
sha1sum (hex)	dd0a03ef6085ff34d46876a5d5a50d521ae44a97
schema:url	https://doi.org/10.1038/s41598-020-66440-9
resource representing a document's title	Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic
has PubMed Central identifier	PMC7283245
has PubMed identifier	32518317
schema:publication	Sci Rep
resource representing a document's body	covid:dd0a03ef6085ff34d46876a5d5a50d521ae44a97#body_text
is schema:about of	named entity 'CORONAVIRUSES' named entity 'vaccine' named entity 'polymerase' named entity 'open' named entity 'multiple alignment' named entity 'possibility' named entity 'polymerase' named entity 'sofosbuvir' named entity 'polymerase' named entity 'pathogens' named entity 'hepatitis c virus' named entity 'epidemic' named entity 'virus' named entity 'therapeutic targets' named entity 'conformations' named entity 'polymerase' named entity 'highly conserved' named entity 'NS5B' named entity 'SARS' named entity 'polymerase' named entity 'GISAID' named entity 'viral diseases' named entity 'mortality rates' named entity 'enzyme' named entity 'ebola' named entity 'MERS' named entity 'coronavirus' named entity 'homology' named entity 'antivirals' named entity 'SARS-CoV-2' named entity 'yellow fever' named entity 'RNA' named entity 'D225' named entity 'conformation' named entity 'nucleotide analogue' named entity 'SARS-CoV-2' named entity 'viral proteins' named entity 'NCBI' named entity 'pneumonia' named entity 'Sofosbuvir' named entity 'SARS-CoV-2' named entity 'WHO' named entity 'coronaviruses' named entity 'Remdesivir' named entity 'exoribonuclease' named entity 'pharmacological' named entity 'RdRp' named entity 'NS5B' named entity 'antivirals' named entity 'active site' named entity 'three-dimensional structure' named entity 'NS5B' named entity 'SARS' named entity 'viruses' named entity 'mutation rate' named entity 'RNA' named entity 'genomes' named entity 'Betacoronavirus' named entity 'SARS' named entity 'SARS-CoV' named entity 'polymerase' named entity 'clinical setting' named entity 'monophyletic' named entity 'HCV' named entity 'coronaviruses' named entity 'SARS-CoV-2' named entity 'traditional Chinese medicines' named entity 'polyprotein' named entity 'SARS-CoV-2' named entity 'proofreading' named entity 'multi-subunit complex' named entity 'Nidovirales' named entity 'SARS-CoV' named entity 'tropical regions' named entity 'nucleotide' named entity 'NS5B' named entity 'nucleoside analogs'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software