About: Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice

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About: Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice
Creator	Bilbao, Izaskun Mazzeo, Carla Sanz, Veronica De Zulueta, Ana Del Pozo, Victoria Gá Mez, Cristina Jesú S Ruiz-Cabello, Rodriguez, Ainara Zafra, Paz Zubeldia, Jose
source	PMC
abstract	Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The objective of this study was to evaluate if delivering of SOCS3 short interfering RNA (siRNA) intranasally in lungs could be a good therapeutic approach in an asthma chronic mouse model. Our results showed that intranasal treatment with SOCS3-siRNA led to an improvement in the eosinophil count and the normalization of hyperresponsiveness to methacholine. Concomitantly, this treatment resulted in an improvement in mucus secretion, a reduction in lung collagen, which are prominent features of airway remodeling. The mechanism implies JAK/STAT and RhoA/Rho-kinase signaling pathway, because we found a decreasing in STAT3 phosphorylation status and down regulation of RhoA/Rho-kinase protein expression. These results might lead to a new therapy for the treatment of chronic asthma.
has issue date	2014-03-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0091996
bibo:pmid	24637581
has license	cc-by
sha1sum (hex)	dcb83fc0259abca0186d62b0b1d32eaf8607fcfc
schema:url	https://doi.org/10.1371/journal.pone.0091996
resource representing a document's title	Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice
has PubMed Central identifier	PMC3956882
has PubMed identifier	24637581
schema:publication	PLoS One
resource representing a document's body	covid:dcb83fc0259abca0186d62b0b1d32eaf8607fcfc#body_text
is schema:about of	named entity 'regulate' named entity 'The mechanism' named entity 'correlated' named entity 'expression' named entity 'proteins' named entity 'siRNA' named entity 'PROTEIN EXPRESSION' named entity 'ASTHMATIC' named entity 'INCREASED' named entity 'GOOD' named entity 'ASTHMA' named entity 'EVALUATE' named entity 'MECHANISM' named entity 'STATUS' named entity 'STAT3' named entity 'SHORT INTERFERING RNA' named entity 'JAK' named entity 'COULD BE' named entity 'METHACHOLINE' named entity 'RESULTS' named entity 'NORMALIZATION' named entity 'LEAD' named entity 'CYTOKINE ' named entity 'STUDY' named entity 'DELIVERY' named entity 'GENE SILENCING' named entity 'PHOSPHORYLATION' named entity 'OBJECTIVE' named entity 'DISEASE SEVERITY' named entity 'COLLAGEN' named entity 'RHOA' named entity 'LED' named entity 'MICE' named entity 'INTRANASAL' named entity 'SIRNA' named entity 'DECREASING' named entity 'DOWN REGULATION' named entity 'PROTEINS' named entity 'AIRWAY REMODELING' named entity 'PROMINENT' named entity 'RESPONSES' named entity 'REDUCTION' named entity 'TREATMENT' named entity 'MOUSE MODEL' named entity 'CORRELATED' named entity 'BALANCE' named entity 'NEW THERAPY' named entity 'LUNG' named entity 'SIGNALING PATHWAY' named entity 'FEATURES' named entity 'REGULATE' named entity 'OUR' named entity 'INTRANASAL' named entity 'SIRNA' named entity 'CYTOKINE SIGNALING' named entity 'THESE' named entity 'FOUND' named entity 'THERAPEUTIC' named entity 'KINASE' named entity 'HAVE' named entity 'SOCS3' named entity 'CONFIRMED' named entity 'PHENOTYPE' named entity 'EOSINOPHIL COUNT' named entity 'IMPROVEMENT' named entity 'LUNGS' named entity 'STUDIES' named entity 'APPROACH' named entity 'ASTHMA CHRONIC' named entity 'IMMUNE' named entity 'EXPRESSION' named entity 'KINASE PROTEIN'

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