About: TIGIT limits immune pathology during viral infections

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: TIGIT limits immune pathology during viral infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TIGIT limits immune pathology during viral infections
Creator	Kipar, Anja Oxenius, Annette Hunziker, Annika Stertz, Silke Joller, Nicole Lambert, Katharina Pallmer, Katharina Rakebrandt, Nikolas Schorer, Michelle
Source	Medline; PMC
abstract	Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection. Importantly, TIGIT signaling is functionally linked to IL-10 expression, which has an effect on both virus control and maintenance of tissue homeostasis. However, whether TIGIT has a function in viral persistence or limiting tissue pathology is unclear. Here we report that TIGIT modulation effectively alters the phenotype and cytokine profile of T cells during influenza and chronic LCMV infection, but does not affect virus control in vivo. Instead, TIGIT has an important effect in limiting immune pathology in peripheral organs by inducing IL-10. Our data therefore identify a function of TIGIT in limiting immune pathology that is independent of viral clearance.
has issue date	2020-03-09(xsd:dateTime)
bibo:doi	10.1038/s41467-020-15025-1
bibo:pmid	32152316
has license	cc-by
sha1sum (hex)	dc1597af8d62d0c917db2647c6b908ad346d6142
schema:url	https://doi.org/10.1038/s41467-020-15025-1
resource representing a document's title	TIGIT limits immune pathology during viral infections
has PubMed Central identifier	PMC7062903
has PubMed identifier	32152316
schema:publication	Nat Commun
resource representing a document's body	covid:dc1597af8d62d0c917db2647c6b908ad346d6142#body_text
is schema:about of	named entity 'FUNCTION' named entity 'EFFICIENT' named entity 'AFFECT' named entity 'TISSUE' named entity 'IMMUNE' named entity 'ORGANS' named entity 'BUT' named entity 'FUNCTIONS' named entity 'PATHWAYS' named entity 'OUR' named entity 'PATHOLOGY' named entity 'TISSUE HOMEOSTASIS' named entity 'REPORT' named entity 'UNCLEAR' named entity 'EXPRESSION' named entity 'REGULATING' named entity 'INFLUENZA' named entity 'CONTROL' named entity 'RESPONSES' named entity 'LIMITING' named entity 'EFFECT' named entity 'HAVE' named entity 'TIGIT' named entity 'IL-10' named entity 'MAINTENANCE' named entity 'DOES NOT' named entity 'CYTOKINE PROFILE' named entity 'T CELLS' named entity 'BALANCE' named entity 'PERIPHERAL' named entity 'IDENTIFY' named entity 'VIRAL INFECTION' named entity 'PHENOTYPE' named entity 'MODULATION' named entity 'LCMV' named entity 'HERE' named entity 'VIRAL PERSISTENCE' named entity 'DATA' named entity 'T CELL DYSFUNCTION' named entity 'PROMOTING' named entity 'VIRAL CLEARANCE' named entity 'LIMITS' named entity 'IMMUNE' named entity 'VIRAL INFECTIONS' named entity 'PATHOLOGY' named entity 'TIGIT' named entity 'INDUCING' named entity 'T CELL' named entity 'INDEPENDENT OF' named entity 'CHRONIC' named entity 'EFFECTOR' named entity 'INHIBITORY' named entity 'RESTRICTING' named entity 'PATHWAY' named entity 'SIGNALING' named entity 'VIRUS' named entity 'INFECTION' named entity 'IMPORTANT' named entity 'IN VIVO' named entity 'infection' named entity 'TNF-α' named entity 'Life technologies' named entity 'infection' named entity 'TIGIT' named entity 'IL-10' named entity 'virus' named entity 'myeloid cells' named entity 'TIGIT' named entity 'KO mice' named entity 'standard curve' named entity 'lung' named entity 'IgG1' named entity 'Life technologies'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software