About: BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53

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About: BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53
Creator	Basile, Anna Cotugno, Roberta Gallotta, Dario Romano, Elena Belisario, Maria
Source	Elsevier; Medline; PMC
abstract	Abstract BAG3 is a multi-functional component of tumor cell pro-survival machinery, and its biological functions have been largely associated to proteasome system. Here, we show that BAG3 down-modulation resulted in reduced cell viability and enhanced PEITC-induced apoptosis largely more extensively in HeLa (HPV18+) rather than in C33A (HPV−) cervical carcinoma cell lines. Moreover, we demonstrate that BAG3 suppression led to a decrease of viral E6 oncoprotein and a concomitant recovery of p53 tumor suppressor, the best recognized target of E6 for proteasome degradation. E6 and p53 expression were modulated at protein level, since their respective mRNAs were unaffected. Taken together our findings reveal a novel role for BAG3 as host protein contributing to HPV18 E6-activated pro-survival strategies, and suggest a possible relevance of its expression levels in drug/radiotherapy-resistance of HPV18-bearing cervical carcinomas.
has issue date	2014-11-28(xsd:dateTime)
bibo:doi	10.1016/j.canlet.2014.08.022
bibo:pmid	25175321
has license	els-covid
sha1sum (hex)	daa62909964df8460beed46d24a31319246d4e15
schema:url	https://doi.org/10.1016/j.canlet.2014.08.022
resource representing a document's title	BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53
has PubMed Central identifier	PMC7116956
has PubMed identifier	25175321
schema:publication	Cancer Letters
resource representing a document's body	covid:daa62909964df8460beed46d24a31319246d4e15#body_text
is schema:about of	named entity 'PEITC' named entity 'demonstrate' named entity 'system' named entity 'expression' named entity 'MODULATION' named entity 'THEIR' named entity 'P53' named entity 'ONCOPROTEIN' named entity 'PRO-SURVIVAL' named entity 'APOPTOSIS' named entity 'PROTEIN LEVEL' named entity 'ITS' named entity 'SUGGEST' named entity 'CONCOMITANT' named entity 'SYSTEM' named entity 'CELL VIABILITY' named entity 'CONTRIBUTING' named entity 'NOVEL' named entity 'RECOVERY' named entity 'DRUG' named entity 'LEVELS' named entity 'P53' named entity 'EXPRESSION' named entity 'OUR' named entity 'FUNCTIONAL COMPONENT' named entity 'ROLE' named entity 'ENHANCED' named entity 'VIRAL' named entity 'CARCINOMAS' named entity 'CERVICAL CARCINOMA CELL' named entity 'ACTIVATED' named entity 'BAG3' named entity 'HELA CELLS' named entity 'HPV18' named entity 'TUMOR CELL' named entity 'CERVICAL' named entity 'ASSOCIATED' named entity 'PROTEIN ' named entity 'REVEAL' named entity 'HOST PROTEIN' named entity 'REDUCED' named entity 'PROTEASOME DEGRADATION' named entity 'LARGELY' named entity 'MACHINERY' named entity 'INDUCED' named entity 'MULTI' named entity 'BAG3' named entity 'PEITC' named entity 'BEST' named entity 'RELEVANCE' named entity 'HELA' named entity 'HERE' named entity 'RESISTANCE' named entity 'CELL LINES' named entity 'HPV18' named entity 'RATHER' named entity 'MODULATED' named entity 'STRATEGIES' named entity 'SUPPRESSION' named entity 'UNAFFECTED' named entity 'DECREASE' named entity 'PROTEASOME' named entity 'POSSIBLE' named entity 'BIOLOGICAL FUNCTIONS' named entity 'HAVE' named entity 'FINDINGS' named entity 'TARGET' named entity 'BEARING' named entity 'P53 TUMOR SUPPRESSOR' named entity 'INDUCED' named entity 'MRNAS' named entity 'IS A' named entity 'LED' named entity 'C33A' named entity 'MODULATION' named entity 'APOPTOSIS' named entity 'TAKEN'

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