About: Spatial and temporal dynamics of SARS-CoV-2 in COVID-19 patients: A systematic review and meta-analysis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Spatial and temporal dynamics of SARS-CoV-2 in COVID-19 patients: A systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spatial and temporal dynamics of SARS-CoV-2 in COVID-19 patients: A systematic review and meta-analysis
Creator	Jellingsø, Mads Otto, Morten Sommer, Alexander Weiss, Anne
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The spatial and temporal dynamics of SARS-CoV-2 have been described in case series and retrospective studies. In this study, we provide a coherent overview of the duration of viral detection and viral RNA load in COVID-19 patients, stratified by specimen type, clinical severity, and age. METHOD: We systematically searched PubMed/MEDLINE and Cochrane review database for studies published between 1.11.2019 and 23.04.2020. We pooled the data of selected studies (22/7226 (650 patients) for meta-analysis) to estimate duration of viral detection and visualized viral load over time. FINDINGS: Our analysis showed consistent viral detection from specimen from the upper respiratory tract (URT), the lower respiratory tract (LRT), and faeces, irrespective of the clinical severity of COVID-19. Our analysis suggests that SARS-CoV-2 persists for a longer duration in the LRT compared to the URT in adult patients (5•7 days in mild; 5•9 days in moderate-severe patients). The differences in the duration of viral detection between mild and moderate-severe patients is limited in the LRT, but an indication of longer duration of viral detection for moderate-severe patients was observed in feces (15 days in mild vs. 21 days in moderate-severe patients) and the URT (12 days in mild vs. 16 days in moderate-severe patients). Further, viral load was demonstrated to peak in earlier stages of infection in the URT compared to LRT. INTERPRETATION: This review may aid mathematical modelling and help in defining appropriate endpoints for clinical trails with antivirals in COVID-19. FUNDING: The project has received funding support from Innovation Fund Denmark.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1016/j.ebiom.2020.102916
bibo:pmid	32711256
has license	no-cc
sha1sum (hex)	d9f1be93607fdfe4954f3075fbb66df9c517a887
schema:url	https://doi.org/10.1016/j.ebiom.2020.102916
resource representing a document's title	Spatial and temporal dynamics of SARS-CoV-2 in COVID-19 patients: A systematic review and meta-analysis
has PubMed Central identifier	PMC7374142
has PubMed identifier	32711256
schema:publication	EBioMedicine
resource representing a document's body	covid:d9f1be93607fdfe4954f3075fbb66df9c517a887#body_text
is schema:about of	named entity 'This' named entity 'Method' named entity 'selected' named entity 'compared' named entity 'data' named entity 'detection' named entity 'patients' named entity 'Spatial' named entity 'BACKGROUND' named entity 'VIRAL LOAD' named entity 'INNOVATION' named entity 'SELECTED' named entity 'DURATION' named entity 'OUR' named entity 'SUPPORT' covid:arg/d9f1be93607fdfe4954f3075fbb66df9c517a887 named entity 'funding' named entity 'compared' named entity 'systematically' named entity 'differences' named entity 'patients' named entity 'Funding' named entity 'Denmark' named entity 'observed' named entity 'SARS-CoV-2' named entity 'defining' named entity 'viral load' named entity 'viral' named entity 'http' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'mathematical modelling' named entity 'SARS-CoV-2' named entity 'MEDLINE' named entity 'viral load' named entity 'COVID-19' named entity 'systematic review' named entity 'by-nc-nd' named entity 'aid' named entity 'viral load' named entity 'Standard error' named entity 'load testing' named entity 'meta-analysis' named entity 'clinical significance' named entity 'viral RNA' named entity 'LRT' named entity 'symptom' named entity 'positive test' named entity 'viral load' named entity 'symptom' named entity 'study design' named entity 'SARS-CoV-2' named entity 'symptom' named entity 'outcome measure' named entity 'LRT' named entity 'URT' named entity 'SARS-CoV-2' named entity 'serum' named entity 'virus' named entity 'SARS-CoV-2 virus' named entity 'SARS-CoV-2' named entity 'faeces' named entity 'SARS-CoV-2' named entity 'LRT' named entity 'viral dynamics' named entity 'statistical significance' named entity 'RT-PCR' named entity 'viral RNA' named entity 'LRT' named entity 'urine' named entity 'SARS-CoV-2' named entity 'sampling frequency' named entity 'URT' named entity 'SARS-CoV-2' named entity 'data interpretation' named entity 'URT' named entity 'subgroup analyses'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software