About: J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes
Creator	Wang, Zhen Wang, Z Chen, Dong Qu, Shen Wang, X Zhu, Bing Hu, Chenchan Sun, H Author, Chen, D Jin, Shengwei Bu, L Bu, Le Hu, C Qu, S Sun, Hang Wang, Xingchun Wu, L Wu, Lianpeng
source	Elsevier; Medline; PMC
abstract	Abstract Aims coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients. Methods the multivariate stepwise binary logistic regression analysis was used to test the dose-response effects of FBG levels on the risk of severe and critical condition in COVID-19 patients. Results FBG levels were plotted in quintiles with set at < 4.74, 4.74-5.21, 5.21-5.78, 5.78-7.05, and ≧7.05 mmol/L. The constituent ratio of severe or critical cases in each FBG quintile was 20.7%, 1.7%, 13.8%, 27.1%, and 67.2%, respectively (P < 0.0001). When the second quintile was used as the reference, the adjusted odds ratios (AORs) (95%CI) for the risk of severe/critical condition in COVID-19 was 25.33(2.77, 231.64), 1.00 (Reference), 3.13(0.33, 29.67), 10.59(1.23, 91.24), 38.93(4.36, 347.48) per FBG quintile respectively (P < 0.001). Conclusions we provide evidence of J-shaped associations between FBG and risk of severe and critical condition in non-diabetes patients with COVID-19, with nadir at 4.74-5.78 mmol/L.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1016/j.diabres.2020.108381
bibo:pmid	32853687
has license	els-covid
sha1sum (hex)	d966ee1333a9d2b7af2a15cb6a52145f80ca0a15
schema:url	https://doi.org/10.1016/j.diabres.2020.108381
resource representing a document's title	J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes
has PubMed Central identifier	PMC7445136
has PubMed identifier	32853687
schema:publication	Diabetes Res Clin Pract
resource representing a document's body	covid:d966ee1333a9d2b7af2a15cb6a52145f80ca0a15#body_text
is schema:about of	named entity 'blood glucose' named entity 'coronavirus disease 2019' named entity 'pandemic' named entity 'Journal' named entity 'MULTI' named entity 'MORTALITY' named entity 'GOAL' named entity 'CLINICAL' named entity 'ASSOCIATION' named entity 'CENTERED' named entity 'EVIDENCE FOR' named entity 'clinical evidence' named entity 'fasting' named entity 'retrospective' named entity 'Patients' named entity 'Patients' named entity 'Blood' named entity 'COVID-19' named entity 'Diabetes' named entity 'Glycemic' named entity 'COVID-19.' named entity 'simple correlation' named entity 'statistically significant' named entity 'mmol/L' named entity 'fever' named entity 'glucose' named entity 'COVID-19' named entity 'antiinflammatory' named entity 'diabetes' named entity 'hepatic failure' named entity 'hypoglycemia' named entity 'inflammatory cytokine' named entity 'diabetes' named entity 'COVID' named entity 'risk factor' named entity 'elevated glucose levels' named entity 'MERS-CoV' named entity 'ATP' named entity 'FBG' named entity 'COVID' named entity 'mmol/L' named entity 'diabetes' named entity 'anti-inflammatory' named entity 'sample size' named entity 'risk factor' named entity 'pneumonia' named entity 'COVID' named entity 'anti-oxidant' named entity 'AORs' named entity 'viral infection' named entity 'ADA' named entity 'Student's t-test' named entity 'COVID' named entity 'COVID' named entity 'infection' named entity 'blood glucose levels' named entity 'statistical analysis' named entity 'FBG' named entity 'Wenzhou' named entity 'National Institute for Viral Disease Control and Prevention' named entity 'C.H.' named entity 'mmol/L' named entity 'diabetes'

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