About: Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis

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About: Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis
Creator	Keirstead, Hans Lane, Thomas Nistor, Gabriel Totoiu, Minodora
Source	Elsevier; Medline; PMC
abstract	Abstract The behavior and myelinogenic properties of glial cells have been well documented following transplantation into regions of focal experimental demyelination in animal models. However, the ability of glial cell preparations to remyelinate in such models does not necessarily indicate that their transplantation into demyelinated lesions in clinical disease will be successful. One of the precluding factors in this regard is a greater understanding of the environmental conditions that will support transplant-mediated remyelination. In this study, we determined whether the complex and reactive CNS environment of the mouse hepatitis virus (MHV) model of multiple sclerosis (MS) could support transplant-mediated remyelination. Striatal neural precursors derived from postnatal day 1 mice were committed to a glial cell lineage and labeled. Immunohistochemical staining indicated that this population generated >93% glial cells following differentiation in vitro. Transplantation of glial-committed progenitor cells into the T8 spinal cord of MHV-infected mice demonstrating complete hindlimb paralysis resulted in migration of cells up to 12 mm from the implantation site and remyelination of up to 67% of axons. Transplanted-remyelinated animals contained approximately 2× the number of axons within sampled regions of the ventral and lateral columns as compared to non-transplanted animals, suggesting that remyelination is associated with axonal sparing. Furthermore, transplantation resulted in behavioral improvement. This study demonstrates for the first time that transplant-mediated remyelination is possible in the pathogenic environment of the MHV demyelination model and that it is associated with locomotor improvement.
has issue date	2004-06-30(xsd:dateTime)
bibo:doi	10.1016/j.expneurol.2004.01.028
bibo:pmid	15144852
has license	els-covid
sha1sum (hex)	d7329d423a2663b0dad3899fd5d073862f95cc53
schema:url	https://doi.org/10.1016/j.expneurol.2004.01.028
resource representing a document's title	Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis
has PubMed Central identifier	PMC7125733
has PubMed identifier	15144852
schema:publication	Experimental Neurology
resource representing a document's body	covid:d7329d423a2663b0dad3899fd5d073862f95cc53#body_text
is schema:about of	named entity 'demyelination' named entity 'migration' named entity 'support' named entity 'support' named entity 'multiple sclerosis' named entity 'TRANSPLANTATION' named entity 'DOES NOT' named entity 'DISEASE' named entity 'COMPARED' named entity 'ENVIRONMENTAL' named entity 'DEMYELINATED' named entity 'REGIONS' named entity 'CELLS' named entity 'HAVE' named entity 'FOCAL' named entity 'ONE OF' named entity 'INFECTED' named entity 'LATERAL COLUMNS' named entity 'TRANSPLANTATION' named entity 'LESIONS' named entity 'MODEL OF' named entity 'PRECURSORS' covid:arg/d7329d423a2663b0dad3899fd5d073862f95cc53 named entity 'REACTIVE' named entity 'NEURAL' named entity 'DERIVED' named entity 'SPINAL CORD' named entity 'APPROXIMATELY' named entity 'GENERATED' named entity 'MULTIPLE SCLEROSIS' named entity 'STUDY' named entity 'DETERMINED' named entity 'DIFFERENTIATION' named entity 'POPULATION' named entity 'COMMITTED' named entity 'ENVIRONMENT' named entity 'REGARD' named entity 'BEHAVIOR' named entity 'NUMBER OF AXONS' named entity 'COMPLETE' named entity 'THEIR' named entity 'HINDLIMB PARALYSIS' named entity 'AXONAL' named entity 'PROGENITOR CELLS' named entity 'CONDITIONS' named entity 'LABELED' named entity 'INDICATED' named entity 'MOUSE HEPATITIS VIRUS' named entity 'GLIAL' named entity 'FOLLOWING' named entity 'MULTIPLE SCLEROSIS' named entity 'REMYELINATION' named entity 'COMMITTED' named entity 'DEMYELINATION' named entity 'CONTAINED' named entity 'SPARING' named entity 'CELL LINEAGE' named entity 'RECOVERY' named entity 'CNS' named entity 'REMYELINATION' named entity 'PROGENITOR CELLS' named entity 'PATHOGENIC' named entity 'MHV' named entity 'MODEL OF' named entity 'SPARING' named entity 'IS A' named entity 'PROPERTIES' named entity 'IMMUNOHISTOCHEMICAL STAINING' named entity 'BEHAVIORAL' named entity 'SAMPLED' named entity 'IMPLANTATION SITE' named entity 'ASSOCIATED WITH' named entity 'TRANSPLANTED' named entity 'POSSIBLE' named entity 'ABILITY' named entity 'MODELS' named entity 'GLIAL CELLS' named entity 'EXPERIMENTAL'

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