About: Identification of a linear epitope on the capsid protein of classical swine fever virus

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About: Identification of a linear epitope on the capsid protein of classical swine fever virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a linear epitope on the capsid protein of classical swine fever virus
Creator	Li, Su Sun, Yuan Zhang, Xin Yang, Shuo Li, Na Qiu, Hua-Ji Xu, Jia He, Fan Huang, Jun-Hua Ling, Li-Jun
Source	Elsevier; Medline; PMC
abstract	Abstract The capsid (C) protein of Classical swine fever virus (CSFV) is proposed to play an essential role in the replication and translation of the viral RNA. In this study, a monoclonal antibody (mAb) directed against the C protein was generated with the recombinant C protein expressed in Escherichia coli as immunogen. IFA and IPMA analysis showed that the native C protein of CSFV virions was reactive to the mAb. By truncating the C protein, we identified a linear epitope recognized by the mAb, corresponding to amino acids 61TQDGLYHNKN70 of the CSFV C protein, which is well conserved among pestiviruses. Laser confocal analysis showed that the C protein mainly locates in the cellular nucleoplasm and nucleolus of PK-15 cells. The results have implications for further study of CSFV replication.
has issue date	2011-03-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2011.01.009
bibo:pmid	21255622
has license	els-covid
sha1sum (hex)	d6ed376c58b4945786f08b2d23010d0a29a80f8c
schema:url	https://doi.org/10.1016/j.virusres.2011.01.009
resource representing a document's title	Identification of a linear epitope on the capsid protein of classical swine fever virus
has PubMed Central identifier	PMC7114404
has PubMed identifier	21255622
schema:publication	Virus Research
resource representing a document's body	covid:d6ed376c58b4945786f08b2d23010d0a29a80f8c#body_text
is schema:about of	named entity 'IDENTIFICATION' named entity 'protein' named entity 'viral' named entity 'generated' named entity 'protein' named entity 'PK-' named entity 'PROTEIN ' named entity 'NATIVE' named entity 'GENERATED' named entity 'PESTIVIRUSES' named entity 'IDENTIFIED' named entity 'ROLE' named entity 'RECOMBINANT' named entity 'CELLS' named entity 'LASER' named entity 'HAVE' named entity 'REPLICATION' named entity 'ESCHERICHIA COLI' named entity 'CONSERVED' named entity 'CLASSICAL SWINE FEVER VIRUS' named entity 'CELLULAR' named entity 'IFA' named entity 'ESSENTIAL' named entity 'IMMUNOGEN' named entity 'EXPRESSED' named entity 'VIRAL RNA' named entity 'MONOCLONAL ANTIBODY' named entity 'REACTIVE' named entity 'STUDY' named entity 'NUCLEOLUS' named entity 'DIRECTED' named entity 'AMINO ACIDS' named entity 'CAPSID' named entity 'RESULTS' named entity 'CLASSICAL SWINE FEVER VIRUS' named entity 'EPITOPE' named entity 'EPITOPE' named entity 'PROTEIN ' named entity 'NUCLEOPLASM' named entity 'PROPOSED' named entity 'PLAY' named entity 'TRANSLATION' named entity 'C PROTEIN' named entity 'ANALYSIS' named entity 'LINEAR' named entity 'VIRIONS' named entity 'MAB' named entity 'CAPSID PROTEIN' named entity 'LINEAR' covid:arg/d6ed376c58b4945786f08b2d23010d0a29a80f8c named entity 'mAb' named entity 'nucleolus' named entity 'capsid' named entity 'virions' named entity 'nucleoplasm' named entity 'immunogen' named entity 'RNA' named entity 'truncating' named entity 'capsid' named entity 'Escherichia coli' named entity 'viral RNA' named entity 'protein' named entity 'protein' named entity 'classical swine fever virus' named entity 'capsid protein' named entity 'reactive' named entity 'CSFV' named entity 'CSFV' named entity 'protein' named entity 'substrate' named entity 'CSFV' named entity 'protein'

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