About: IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner

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About: IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner
Creator	Sakaguchi, Takemasa Honda, Tomoyuki Tomonaga, Keizo Fukuhara, Takasuke Irie, Takashi Kawabata, Ryoko Yoshida, Asuka Suzuki, Nobuhiro Dansako, Hiromichi
Source	Medline; PMC
abstract	The interferon (IFN) system is one of the most important defensive responses of mammals against viruses, and is rapidly evoked when the pathogen-associated molecular patterns (PAMPs) of viruses are sensed. Non-self, virus-derived RNA species have been identified as the PAMPs of RNA viruses. In the present study, we compared different types of IFN-β-inducing and -non-inducing viruses in the context of Sendai virus infection. We found that some types of unusual viral RNA species were produced by infections with IFN-β-inducing viruses and accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner. One of these structures was similar to the so-called antiviral stress granules (avSGs) formed by an infection with IFN-inducing viruses whose C proteins were knocked-out or mutated. Non-encapsidated, unusual viral RNA harboring the 5′-terminal region of the viral genome as well as RIG-I and typical SG markers accumulated in these granules. Another was a non-SG-like inclusion formed by an infection with the Cantell strain; a copyback-type DI genome, but not an authentic viral genome, specifically accumulated in the inclusion, whereas RIG-I and SG markers did not. The induction of IFN-β was closely associated with the production of these unusual RNAs as well as the formation of the cytoplasmic structures.
has issue date	2015-08-04(xsd:dateTime)
bibo:doi	10.3389/fmicb.2015.00804
bibo:pmid	26300870
has license	cc-by
sha1sum (hex)	d6ea3039fed0942c355cabc8a67f7226cd05fc8c
schema:url	https://doi.org/10.3389/fmicb.2015.00804
resource representing a document's title	IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner
has PubMed Central identifier	PMC4523817
has PubMed identifier	26300870
schema:publication	Front Microbiol
resource representing a document's body	covid:d6ea3039fed0942c355cabc8a67f7226cd05fc8c#body_text
is schema:about of	named entity 'RNA' named entity 'UNUSUAL' named entity 'ACCUMULATED' named entity 'JOURNAL ' named entity 'UNUSUAL' named entity 'C PROTEINS' named entity 'FORMATION' named entity 'VIRAL RNA' named entity 'PARAMYXOVIRUS' named entity 'NON-' named entity 'COMPARED' named entity 'ACCUMULATED' named entity 'VIRUS' named entity 'ASSOCIATED' covid:arg/d6ea3039fed0942c355cabc8a67f7226cd05fc8c named entity 'INFECTION' named entity 'PATHOGEN' named entity 'MOLECULAR' named entity 'PRESENT' named entity 'STRESS' named entity 'VIRAL RNA' named entity 'LIKE' named entity 'PRODUCTION' named entity 'MUTATED' named entity 'INDUCTION' named entity 'SIMILAR' named entity 'INCLUSION' named entity 'TERMINAL' named entity 'INFECTION' named entity 'IMPORTANT' named entity 'TYPES' named entity 'ONE OF' named entity 'SECTION' named entity 'DISTINCT' named entity 'TYPE' named entity 'MICROBIOLOGY' named entity 'SPECIES' named entity 'INDUCING' named entity 'CYTOPLASMIC STRUCTURES' named entity 'INDUCING' named entity 'IDENTIFIED' named entity 'REGION' named entity 'STRUCTURES' named entity 'EVOKED' named entity 'CONTEXT' named entity 'THESE' named entity 'SPECIES' named entity 'ANTIVIRAL' named entity 'SYSTEM' named entity 'IFN' named entity 'RAPIDLY' named entity 'DIFFERENT' named entity 'STUDY' named entity 'HAVE' named entity 'DID' named entity 'INTERFERON ' named entity 'CYTOPLASMIC STRUCTURES' named entity 'ASSOCIATED WITH' named entity 'TYPE' named entity 'PATTERNS' named entity 'MARKERS' named entity 'INFECTIONS' named entity 'MAMMALS' named entity 'VIRUSES' named entity 'PAMPS' named entity 'DISTINCT' named entity 'TYPICAL' named entity 'GRANULES' named entity 'DEPENDENT' named entity 'FORMED' named entity 'RESPONSES' named entity 'VIRAL GENOME' named entity 'RIG-I'

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