About: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens
Creator	Addo, Marylyn Dahlke, Christine Fathi, Anahita
topic	covid:d690e4df20380e92f907315e831f39116b1c460d#this
Source	Medline; PMC
abstract	The devastating Ebola virus (EBOV) outbreak in West Africa in 2013–2016 has flagged the need for the timely development of vaccines for high-threat pathogens. To be better prepared for new epidemics, the WHO has compiled a list of priority pathogens that are likely to cause future outbreaks and for which R&D efforts are, therefore, paramount (R&D Blueprint: https://www.who.int/blueprint/priority-diseases/en/). To this end, the detailed characterization of vaccine platforms is needed. The vesicular stomatitis virus (VSV) has been established as a robust vaccine vector backbone for infectious diseases for well over a decade. The recent clinical trials testing the vaccine candidate VSV-EBOV against EBOV disease now have added a substantial amount of clinical data and suggest VSV to be an ideal vaccine vector candidate for outbreak pathogens. In this review, we discuss insights gained from the clinical VSV-EBOV vaccine trials as well as from animal studies investigating vaccine candidates for Blueprint pathogens.
has issue date	2019-09-05(xsd:dateTime)
bibo:doi	10.1080/21645515.2019.1649532
bibo:pmid	31368826
has license	cc-by-nc-nd
sha1sum (hex)	d690e4df20380e92f907315e831f39116b1c460d
schema:url	https://doi.org/10.1080/21645515.2019.1649532
resource representing a document's title	Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens
has PubMed Central identifier	PMC6816421
has PubMed identifier	31368826
schema:publication	Hum Vaccin Immunother
resource representing a document's body	covid:d690e4df20380e92f907315e831f39116b1c460d#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d690e4df20380e92f907315e831f39116b1c460d
is schema:about of	named entity 'EBOLA VIRUS' named entity 'INFECTIOUS DISEASES' named entity 'VACCINES' named entity 'HTTPS' named entity 'GAINED' named entity 'PRIORITY' named entity 'IDEAL' named entity 'DEVELOPMENT' named entity 'OUTBREAK' named entity 'CAUSE' named entity 'LIST' named entity 'WEST AFRICA' named entity 'NEEDED' named entity 'ROBUST' named entity 'TESTING' named entity 'INVESTIGATING' named entity 'END' named entity 'ESTABLISHED' named entity 'VECTOR' named entity 'EPIDEMICS' named entity 'vesicular stomatitis virus' named entity 'pathogens' named entity 'Recombinant' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'TIMELY' named entity 'CANDIDATE' named entity 'VACCINE' named entity 'VIRUS VECTOR' named entity 'PATHOGENS' named entity 'RECOMBINANT' named entity 'VACCINES' named entity 'CLINICAL TRIALS' named entity 'NEED FOR' named entity 'BACKBONE' named entity 'BETTER' named entity 'DISCUSS' named entity 'SUGGEST' named entity 'HAVE' named entity 'LIKELY' named entity 'ADDED' named entity 'NEW' named entity 'VACCINE CANDIDATE' named entity 'CLINICAL DATA' named entity 'CHARACTERIZATION' named entity 'DISEASE' named entity 'RECENT' named entity 'DISEASES' named entity 'REVIEW' named entity 'PRIORITY' named entity 'PREPARED' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'DETAILED' named entity 'HIGH' named entity 'FUTURE' named entity 'INT' named entity 'PATHOGENS' named entity 'ANIMAL STUDIES' named entity 'CLINICAL' named entity 'INSIGHTS' named entity 'DECADE' named entity 'THREAT' named entity 'detailed' named entity 'animal studies' named entity 'R&D' named entity 'blueprint' named entity 'preventive vaccine' named entity 'pulmonary infections' named entity 'genetically divergent' named entity 'tropism' named entity 'single-shot' named entity 'EBOV' named entity 'Severe fever with thrombocytopenia syndrome' named entity 'EVD' named entity 'West African' named entity 'Ebola virus' named entity 'vaccine' named entity 'vaccine'

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