About: A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae

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About: A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae
Creator	Canard, Bruno Decroly, Etienne Debat, Humberto Ois Ferron, Franç Shannon, Ashleigh
source	Medline; PMC
abstract	The order Nidovirales is a diverse group of (+)RNA viruses, classified together based on their common genome organisation and conserved replicative enzymes, despite drastic differences in size and complexity. One such difference pertains to the mechanisms and enzymes responsible for generation of the proposed viral 5′ RNA cap. Within the Coronaviridae family, two separate methytransferases (MTase), nsp14 and nsp16, perform the RNA-cap N7-guanine and 2′-OH methylation respectively for generation of the proposed m7GpppNm type I cap structure. For the majority of other families within the Nidovirales order, the presence, structure and key enzymes involved in 5′ capping are far less clear. These viruses either lack completely an RNA MTase signature sequence, or lack an N7-guanine methyltransferase signature sequence, obscuring our understanding about how RNA-caps are N7-methylated for these families. Here, we report the discovery of a putative Rossmann fold RNA methyltransferase in 10 Tobaniviridae members in Orf1a, an unusual genome locus for this gene. Multiple sequence alignments and structural analyses lead us to propose this novel gene as a typical RNA-cap N7-guanine MTase with substrate specificity and active-site organization similar to the canonical eukaryotic RNA-cap N7-guanine MTase.
has issue date	2019-12-19(xsd:dateTime)
bibo:doi	10.1093/nargab/lqz022
bibo:pmid	32289120
has license	cc-by-nc
sha1sum (hex)	d6332e5d639368ee53f3eb50a27408ff9904055a
schema:url	https://doi.org/10.1093/nargab/lqz022
resource representing a document's title	A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae
has PubMed Central identifier	PMC7107822
has PubMed identifier	32289120
schema:publication	NAR Genom Bioinform
resource representing a document's body	covid:d6332e5d639368ee53f3eb50a27408ff9904055a#body_text
is schema:about of	named entity 'METHYLTRANSFERASE' named entity 'RNA' named entity 'family' named entity 'For' named entity 'clear' named entity 'involved' named entity 'generation' named entity 'GUANINE' named entity 'LARGE' named entity 'CAP' named entity 'SEQUENCE' covid:arg/d6332e5d639368ee53f3eb50a27408ff9904055a named entity 'GENE' named entity 'ACTIVE-SITE' named entity 'RESPONSIBLE' named entity 'ENZYMES' named entity 'CAP' named entity 'ORGANIZATION' named entity 'OUR' named entity 'PRESENCE' named entity 'RNA METHYLTRANSFERASE' named entity 'ABOUT' named entity 'PROPOSED' named entity 'MTASE' named entity 'EITHER' named entity 'TYPE I' named entity 'CONSERVED' named entity 'SUBSTRATE SPECIFICITY' named entity 'TOBANIVIRIDAE' named entity 'NON-MAMMALIAN' named entity 'GENOME' named entity 'RNA' named entity 'FOLD' named entity 'BASED' named entity 'SEQUENCE' named entity 'MECHANISMS' named entity 'GENETIC MARKER' named entity 'LACK' named entity 'NIDOVIRALES' named entity 'HOW' named entity 'FAR' named entity 'IS A' named entity 'FAMILY' named entity 'RNA' named entity 'THESE' named entity 'COMMON' named entity 'SEPARATE' named entity 'DIVERSE' named entity 'EUKARYOTIC' named entity 'CAPS' named entity 'ORDER NIDOVIRALES' named entity 'STRUCTURE' named entity 'DIFFERENCE' named entity 'COMPLEXITY' named entity 'DISCOVERY' named entity 'METHYLATION' named entity 'CORONAVIRIDAE' named entity 'SIMILAR' named entity 'REPORT' named entity 'THEIR' named entity 'GENOME' named entity 'GROUP' named entity 'SIGNATURE' named entity 'TYPICAL' named entity 'STRUCTURAL' named entity 'CAP STRUCTURE' named entity 'PERFORM' named entity 'METHYLTRANSFERASE' named entity 'GUANINE' named entity 'ORDER' named entity 'KEY' named entity 'GENERATION' named entity 'LOCUS' named entity 'INVOLVED' named entity 'SIGNATURE' named entity 'UNDERSTANDING' named entity 'FAMILIES'

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