About: Immunologic characterization of a immunosuppressed multiple sclerosis patient that recovered from SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immunologic characterization of a immunosuppressed multiple sclerosis patient that recovered from SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunologic characterization of a immunosuppressed multiple sclerosis patient that recovered from SARS-CoV-2 infection
Creator	Imberti, Luisa Badolato, Raffaele Capra, Ruggero Chiarini, Marco De Rossi, Nicola Giacomelli, Mauro Moratto, Daniele Paghera, Simone
Source	Elsevier; Medline; PMC
abstract	A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. High levels of CCL5 and CCL10 chemokines and of antibody-secreting B cells were detected, while the levels other B- and T-cell subsets were comparable to that of appropriate controls. However, CD4+ and CD8+ cells were oligoclonally expanded and prone to apoptosis when stimulated in vitro. This study suggests that fingolimod-immunosuppressed patients, despite the low circulating lymphocytes, may rapidly expand antibody-secreting cells and mount an effective immune response that favors COVID-19 recovery after discontinuation.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2020.577282
bibo:pmid	32505908
has license	no-cc
sha1sum (hex)	d5cdd803f6b35b52bd78d9ab82dd10d552b798fd
schema:url	https://doi.org/10.1016/j.jneuroim.2020.577282
resource representing a document's title	Immunologic characterization of a immunosuppressed multiple sclerosis patient that recovered from SARS-CoV-2 infection
has PubMed Central identifier	PMC7256606
has PubMed identifier	32505908
schema:publication	J Neuroimmunol
resource representing a document's body	covid:d5cdd803f6b35b52bd78d9ab82dd10d552b798fd#body_text
is schema:about of	named entity 'CCL5' named entity 'detected' named entity 'expand' named entity 'However' named entity 'MODERATE' named entity 'IMMUNOLOGIC' named entity 'PROOF' named entity 'PATIENT' named entity 'apoptosis' named entity 'B cells' named entity 'effective' named entity 'chemokines' named entity 'levels' named entity 'circulating' named entity 'CCL10' named entity 'antibody' named entity 'CD4+' named entity 'clinical features' named entity 'immunosuppressed' named entity 'SARS-CoV-2' named entity 'chemokines' named entity 'CCL5' named entity 'T-cell' named entity 'infection' named entity 'immunosuppressed' named entity 'SARS-CoV-2' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Immunologic' named entity 'COVID-19' named entity 'heterogeneity' named entity 'IFN-beta' named entity 'APC' named entity 'APC' named entity 'recombination' named entity 'IL-10' named entity 'CD3' named entity 'CD4' named entity 'Italy' named entity 'Italian programme' named entity 'CDR3' named entity 'real-time PCR' named entity 'infection' named entity 'lymphocytes' named entity 'CD4' named entity 'chemokine' named entity 'SARS-CoV-2' named entity 'T-cell receptor' named entity 'community-acquired' named entity 'informed consent' named entity 'primary and secondary lymphoid organs' named entity 'IFN-γ' named entity 'asymptomatic' named entity 'hydroxychloroquine' named entity 'IL-2' named entity 'fingolimod' named entity 'CD4+ cells' named entity 'immune response' named entity 'lymphocytes' named entity 'chest radiography' named entity 'continuous positive airway pressure' named entity 'mitoxantrone' named entity 'fingolimod' named entity 'lymphocytes' named entity 'CD3' named entity 'COVID-19' named entity 'COVID' named entity 'teriflunomide' named entity 'serological test' named entity 'CD8+' named entity 'oxygen saturation' named entity 'Th1' named entity 'lymphocyte subsets' named entity 'CD3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software