About: The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases
Creator	Haas, Jürgen Griffiths, Samantha Russell, Clark Dunnigan, Cory
Source	Medline; PMC
abstract	Since its discovery in 2003, the type III interferon-λ (IFN-λ) family has been found to contribute significantly to the host response to infection. Whilst IFN-λ shares many features with type I IFN induction and signalling pathways, the tissue-specific restricted expression of its receptor, IL28RA, makes IFN-λ a major mediator of host innate immunity in tissues and organs with a high epithelial cell content. Host susceptibility and responses to infection are known to be heterogeneous, and the identification of common genetic variants linked to disease outcome by genome-wide association studies (GWAS) has underscored the significance of host polymorphisms in responses to infection. Several such GWAS have highlighted the IFN-λ locus on chromosome 19q13 as an area of genetic variation significantly associated with hepatitis C virus (HCV) infection, and the rs12979860 genotype can be used in clinical practice as a biomarker for predicting a successful response to treatment with pegylated IFN and ribavarin. Here, we discuss IFN-λ genetic polymorphisms and their role in HCV and other infectious diseases as well as their potential impact on clinical diagnostics, patient stratification and therapy. Finally, the broader role of IFN-λ in the immunopathogenesis of non-infectious inflammatory diseases is considered.
has issue date	2015-01-23(xsd:dateTime)
bibo:doi	10.1159/000369902
bibo:pmid	25634147
has license	green-oa
sha1sum (hex)	d4510ed504459f18bac7427dfdab1be2a1ccad01
schema:url	https://doi.org/10.1159/000369902
resource representing a document's title	The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases
has PubMed Central identifier	PMC6738896
has PubMed identifier	25634147
schema:publication	Journal of Innate Immunity
resource representing a document's body	covid:d4510ed504459f18bac7427dfdab1be2a1ccad01#body_text
is schema:about of	named entity 'HCV' named entity 'infectious diseases' named entity 'THERAPY' named entity 'OTHER INFECTIOUS DISEASES' named entity 'clinical diagnostics' named entity 'immunopathogenesis' named entity 'non-infectious' named entity 'Infectious Diseases' named entity 'Hepatitis' named entity 'heterochromatic' named entity 'miR-122' named entity 'alleles' named entity 'genotype' named entity 'SLE' named entity 'biomarkers' named entity 'Asian Australians' named entity 'HCV' named entity 'dengue virus' named entity 'IFN-κ' named entity 'HCV' named entity 'polymorphism' named entity 'genetic variations' named entity 'genetic polymorphisms' named entity 'HCV' named entity 'Methylation' named entity 'SNP' named entity 'patient cohorts' named entity 'IFN-α' named entity 'transcription activators' named entity 'SNP' named entity 'STAT1' named entity 'hepatitis' named entity 'IRF7' named entity 'IFN-λ' named entity 'IFN-λ' named entity 'HTLV-1' named entity 'chronic hepatitis' named entity 'transcriptionally active' named entity 'HTLV' named entity 'genotype' named entity 'SNPs' named entity 'mechanical ventilation' named entity 'IFN-λ' named entity 'herpes simplex virus' named entity 'correlation' named entity 'virus-induced cancers' named entity 'IL28B' named entity 'pathogens' named entity 'mutation' named entity 'disease susceptibility' named entity 'SNP' named entity 'bacteria' named entity 'IFN-λ' named entity 'CMV' named entity 'disease control' named entity 'polymorphisms' named entity 'hepatocytes' named entity 'genotype' named entity 'homozygous' named entity 'IFN-λ' named entity 'liver' named entity 'co-infected' named entity 'allele' named entity 'ISG' named entity 'IL28B' named entity 'chromatin accessibility' named entity 'receptor expression' named entity 'HCV' named entity 'HCV' named entity 'IFN-γ' named entity 'promoter region' named entity 'allele' named entity 'virological' named entity 'IFN-λ' named entity 'herpes' named entity 'DNA viruses' named entity 'autoimmune disease' named entity 'oncogenic viruses'

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