About: A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

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About: A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
Creator	Kollmus, Heike Becker, Lore Bogue, Molly Calzada-Wack, Julia Fuchs, Helmut Graw, Jochen Hans, Wolfgang Hölter, Sabine Klein-Rodewald, Tanja Lengger, Christoph Mayer-Kuckuk, Philipp Moreth, Kristin Rozman, Jan Rácz, Ildikó Spielmann, Nadine Treise, Irina Adler, · Aguilar-Pimentel, Antonio Amarie, Veronica Beckers, · Busch, · Haselimashhadi, · Horsch, · Juan, · Lillian Garrett, · Maier, · Miller, · Neff, · Oana, · Rathkolb, · Thomas, ·
Source	PMC
abstract	The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00335-020-09827-3) contains supplementary material, which is available to authorized users.
has issue date	2020-02-14(xsd:dateTime)
bibo:doi	10.1007/s00335-020-09827-3
bibo:pmid	32060626
has license	cc-by
sha1sum (hex)	d4263fdd583a9f901871884096f160977bac8986
schema:url	https://doi.org/10.1007/s00335-020-09827-3
resource representing a document's title	A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
has PubMed Central identifier	PMC7060152
has PubMed identifier	32060626
schema:publication	Mamm Genome
resource representing a document's body	covid:d4263fdd583a9f901871884096f160977bac8986#body_text
is schema:about of	named entity 'blood chemistry' named entity 'phenome' named entity 'screening' named entity 'identify' named entity 'cardiovascular' named entity 'Yildirim' named entity 'Angelis' named entity 'ALI' named entity 'MARTIN' named entity '2C18' named entity 'TO IDENTIFY' named entity 'STRAINS' named entity 'DATABASE' named entity 'FEMALES' named entity 'PERFORMED' named entity 'IMMUNOLOGY' named entity 'SCREENING' named entity 'CLINICAL' named entity 'VALUE' named entity 'LUNG FUNCTION' named entity 'NZO' named entity 'LARGE' named entity 'PWK' named entity 'MALES' named entity 'NEUROLOGY' named entity 'INBRED' named entity '129S1' named entity '300' named entity 'NOCICEPTION' named entity 'COLLABORATIVE' named entity 'FOUNDER' named entity 'LINES' named entity 'BONE AND CARTILAGE' named entity 'WSB' named entity 'IDENTIFIED' named entity 'SIXTEEN' named entity 'DATABASE' named entity 'PHENOTYPE' named entity 'STUDY' named entity 'TOTAL' named entity 'DATA' named entity 'DERIVED' named entity 'CARDIOVASCULAR' named entity 'TRAITS' named entity 'PHENOTYPING' named entity 'GENOTYPE' named entity 'PHENOME' named entity 'TORRES' named entity 'KLAUS' named entity 'TEAM' named entity 'MOUSE'

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