About: Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads

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About: Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads
Creator	Balzarini, Jan Serpi, Michaela Hamon, Nadège Slusarczyk, Magdalena Mcguigan, Christopher
source	Elsevier; Medline; PMC
abstract	Abstract 2-Deoxy-α-d-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance. However due to the lack of a stabilising group at its 2-position, it is difficult to synthesize stable prodrugs of this compound. In order to overcome this lack of stability, the synthesis of carbasugar analogues of 2-deoxyribose-1-phosphate was envisioned. Herein the preparation of a series of prodrugs of two carbocyclic analogues of 2-deoxyribose-1-phosphate using the phosphoramidate ProTide technology, along with their biological evaluation against HIV and cancer cell proliferation, is reported.
has issue date	2015-02-15(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2014.12.039
bibo:pmid	25616343
has license	els-covid
sha1sum (hex)	d170f3ce0214d6b9b4c1b3f79c52213d8cde65d6
schema:url	https://doi.org/10.1016/j.bmc.2014.12.039
resource representing a document's title	Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads
has PubMed Central identifier	PMC7127161
has PubMed identifier	25616343
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:d170f3ce0214d6b9b4c1b3f79c52213d8cde65d6#body_text
is schema:about of	named entity 'great' named entity 'Synthesis' named entity 'RIBOSE-1-PHOSPHATE' named entity 'SYNTHESIS' named entity 'POTENTIAL' named entity 'PHOSPHORAMIDATE' named entity 'DIRECTED' named entity 'BIOSYNTHESIS' named entity 'DUE TO' named entity 'PRODRUGS' named entity '2-DEOXYRIBOSE' named entity 'DEOXY' named entity 'PHOSPHORAMIDATE' named entity 'GREAT' named entity 'DEGRADATION' named entity 'ANTI-HIV' named entity 'PRODRUGS' named entity 'INTEREST' named entity 'ITS' named entity 'THEIR' named entity 'POSITION' named entity 'PHOSPHATE' named entity 'NUCLEOSIDE ANALOGUES' named entity 'RIBOSE-1-PHOSPHATE' named entity 'S T' named entity 'BIOLOGICAL EVALUATION' named entity 'PROTIDE' named entity 'THERAPEUTIC' named entity 'BIOLOGICAL EVALUATION' named entity 'ORDER' named entity 'SYNTHESIZE' named entity 'NEW' named entity 'LACK' named entity 'CARBASUGARS' named entity 'LEADS' named entity 'DIFFICULT' named entity 'RELEVANCE' named entity 'DISCOVERY' named entity '2-DEOXY-D-RIBOSE' named entity 'D-RIBOSE' named entity 'HIV' named entity 'CANCER CELL' named entity 'REPORTED' named entity 'STABLE' named entity 'TECHNOLOGY' named entity 'STABILITY' named entity 'INVOLVED' named entity 'OVERCOME' named entity 'USING' named entity 'SYNTHESIS' named entity 'A-D' named entity 'GROUP' named entity 'SERIES' named entity 'CATABOLIC' named entity 'CELL PROLIFERATION' named entity 'PREPARATION' named entity 'BIOLOGICAL' named entity 'COMPOUND' named entity 'stability' named entity 'analogues' named entity 'carbocyclic' named entity 'deoxyribose' named entity 'catabolic' named entity 'prodrugs' named entity 'analogues' named entity 'compound' named entity '2-deoxyribose' named entity 'ProTide' named entity 'nucleoside analogues' named entity 'phosphoramidate' named entity 'prodrugs' named entity 'ribose-1-phosphate' named entity 'phosphoramidate' named entity 'cell cultures' named entity 'phosphate' named entity 'Hydroboration-oxidation reaction' named entity 'sugar'

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