About: Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker

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About: Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
Creator	Schols, Dominique Andrei, Graciela Snoeck, Robert Głowacka, Iwona Piotrowska, Dorota Emília De Sousa, Maria
Source	Medline; PMC
abstract	A novel series of {4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates and {4-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates as acyclic analogues of guanosine were synthesized and assessed for antiviral activity against a broad range of DNA and RNA viruses and for their cytostatic activity toward three cancerous cell lines (HeLa, L1210 and CEM). They were devoid of antiviral activity; however, several phosphonates were found slightly cytostatic against HeLa cells at an IC(50) in the 80–210 µM range. Compounds (1R,2S)-17k and (1S,2S)-17k showed the highest inhibitory effects (IC(50) = 15–30 µM) against the proliferation of murine leukemia (L1210) and human T-lymphocyte (CEM) cell lines.
has issue date	2015-10-16(xsd:dateTime)
bibo:doi	10.3390/molecules201018789
bibo:pmid	26501246
has license	cc-by
sha1sum (hex)	d107ccddb5e20fc5a311869da6760711f2f1f8e1
schema:url	https://doi.org/10.3390/molecules201018789
resource representing a document's title	Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
has PubMed Central identifier	PMC6332235
has PubMed identifier	26501246
schema:publication	Molecules
resource representing a document's body	covid:d107ccddb5e20fc5a311869da6760711f2f1f8e1#body_text
is schema:about of	named entity 'L1210' named entity 'CELL LINES' named entity '282' named entity 'HELA CELLS' named entity 'PHOSPHONATES' named entity 'NOVEL' named entity 'THEIR' named entity 'OXO' named entity 'RANGE' named entity 'HIGHEST' named entity 'MURINE' named entity 'CYTOSTATIC' named entity 'CHLORO' named entity 'RNA VIRUSES' named entity 'ANTIVIRAL ACTIVITY' named entity 'PROLIFERATION' named entity 'TRIAZOLE' named entity 'DNA' covid:arg/d107ccddb5e20fc5a311869da6760711f2f1f8e1 named entity 'ASSESSED' named entity 'T-LYMPHOCYTE' named entity 'SYNTHESIZED' named entity 'ACYCLIC' named entity 'LEUKEMIA' named entity '210' named entity 'LINKER' named entity 'GUANOSINE' named entity 'CEM' named entity 'FOUND' named entity 'BROAD' named entity 'SLIGHTLY' named entity 'IC50' named entity 'ACYCLIC' named entity 'GUANOSINE' named entity 'HUMAN' named entity 'SERIES' named entity '2C6' named entity 'INHIBITORY' named entity 'MOLECULES' named entity '7B4' named entity 'ACTIVITY' named entity 'AMINO' named entity 'EFFECTS' named entity 'Coxsackie virus' named entity 'Poland' named entity 'Madin-Darby canine kidney cells' named entity 'microwave irradiation' named entity 'hypoxanthine' named entity 'solvent' named entity 'purine' named entity 'H1N1' named entity 'mmol' named entity 'guanines' named entity 'plaque forming units' named entity 'phosphonates' named entity 'oral bioavailability' named entity 'VSV' named entity 'esters' named entity 'prodrug' named entity 'virus' named entity 'inoculated' named entity 'Coxsackie virus' named entity 'ionized' named entity 'HIV-1 and HIV-2' named entity 'phosphonate' named entity 'aqueous' named entity 'L1210' named entity 'solvent' named entity 'carcinoma' named entity 'guanosine' named entity 'corona virus' named entity 'H2O' named entity 'NMR' named entity 'phosphate group' named entity 'oxo' named entity 'HeLa cells'

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