About: Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real-Time Reverse-Transcriptase Polymerase Chain Reaction

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About: Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real-Time Reverse-Transcriptase Polymerase Chain Reaction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real-Time Reverse-Transcriptase Polymerase Chain Reaction
Creator	Schuurman, Rob Nijhuis, Monique Van Elden, Leontine Van Loon, Anton Hoepelman, Andy Hendriksen, Karin Oosterheert, Jan-Jelrik Schipper, Pauline Van Kraaij, Marian Van Alphen, Floris
Source	Medline; PMC
abstract	During the past years, human coronaviruses (HCoVs) have been increasingly identified as pathogens associated with more-severe respiratory tract infection (RTI). Diagnostic tests for HCoVs are not frequently used in the routine setting. It is likely that, as a result, the precise role that HCoVs play in RTIs is greatly underestimated. We describe a rapid, sensitive, and highly specific quantitative real-time reverse-transcriptase polymerase chain reaction (RT-PCR) for the detection of HCoV that can easily be implemented in the routine diagnostic setting. HCoV was detected in 28 (11%) of the 261 clinical specimens obtained from patients presenting with symptoms of RTI ranging from common cold to severe pneumonia. Only 1 (0.4%) of the 243 control specimens obtained from patients without symptoms of RTI showed the presence of HCoV. We conclude that HCoVs can be frequently detected in patients presenting with RTI. Real-time RT-PCR provides a tool for large-scale epidemiological studies to further clarify the role that coronavirus infection plays in RTI in humans.
has issue date	2004-02-01(xsd:dateTime)
bibo:doi	10.1086/381207
bibo:pmid	14767819
has license	no-cc
sha1sum (hex)	d0f4b6cbebcae6a0fa9a145e74783391ca8cada9
schema:url	https://doi.org/10.1086/381207
resource representing a document's title	Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real-Time Reverse-Transcriptase Polymerase Chain Reaction
has PubMed Central identifier	PMC7110206
has PubMed identifier	14767819
schema:publication	J Infect Dis
resource representing a document's body	covid:d0f4b6cbebcae6a0fa9a145e74783391ca8cada9#body_text
is schema:about of	named entity 'precise' named entity 'tests' named entity 'setting' named entity 'Human' named entity 'Specimens' named entity 'RESPIRATORY TRACT INFECTION' named entity 'FREQUENT' named entity 'POLYMERASE CHAIN REACTION' named entity 'CORONAVIRUSES' named entity 'PATIENTS' named entity 'SENSITIVE' named entity 'HUMAN' named entity 'HIGHLY' named entity 'SEVERE PNEUMONIA' named entity 'RAPID' named entity 'COMMON COLD' named entity 'SPECIFIC' covid:arg/d0f4b6cbebcae6a0fa9a145e74783391ca8cada9 named entity 'DETECTION' named entity 'RESULT' named entity 'PRECISE' named entity 'POLYMERASE CHAIN REACTION' named entity 'OBTAINED' named entity 'PCR' named entity 'RTI' named entity 'IMPLEMENTED' named entity 'EASILY' named entity 'CORONAVIRUSES' named entity 'REAL-TIME' named entity 'SPECIMENS' named entity 'USE OF' named entity 'IDENTIFIED' named entity 'SEVERE' named entity 'ROUTINE' named entity 'SPECIMENS' named entity 'REVERSE-TRANSCRIPTASE' named entity 'CLINICAL' named entity 'PATIENTS' named entity 'HAVE' named entity 'GREATLY' named entity 'CLINICAL' named entity 'PLAY' named entity 'HUMAN' named entity 'NOVEL' named entity 'DIAGNOSTIC' named entity 'DIAGNOSTIC TESTS' named entity 'REAL-TIME' named entity 'ASSOCIATED WITH' named entity 'DESCRIBE' named entity 'RESPIRATORY TRACT INFECTION' named entity 'FREQUENTLY' named entity 'SYMPTOMS' named entity 'SETTING' named entity 'PRESENCE OF' named entity 'YEARS' named entity 'QUANTITATIVE' named entity 'REVERSE-TRANSCRIPTASE' named entity 'ROLE' named entity 'PRESENTING' named entity 'LIKELY' named entity 'PAST' named entity 'CONCLUDE' named entity 'CONTROL' named entity 'DETECTION' named entity 'PATHOGENS' named entity 'USED' named entity 'DETECTED' named entity 'presenting' named entity 'respiratory tract' named entity 'RTI' named entity 'RTI' named entity 'setting'

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