About: Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology

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About: Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology
Creator	Ziebuhr, John Weiss, Susan Zhao, Ling Elliott, Ruth Wu, Ashley Gorbalenya, Alexander Jha, Babal Silverman, Robert
Source	Elsevier; Medline; PMC
abstract	Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse hepatitis virus (MHV), causes acute hepatitis in its natural host and provides a useful model for understanding virus interaction with liver cells. The MHV accessory protein, ns2, antagonizes the type I interferon response and promotes hepatitis. We show that ns2 has 2’,5’-phosphodiesterase activity, which blocks the interferon inducible 2’,5’-oligoadenylate synthetase (OAS)-RNase L pathway to facilitate hepatitis development. Ns2 cleaves 2’, 5’-oligoadenylate, the product of OAS, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RNA degradation. An ns2 mutant virus was unable to replicate in the liver or induce hepatitis in wild type mice, but was highly pathogenic in RNase L deficient mice. Thus, RNase L is a critical cellular factor for protection against viral infection of the liver and the resulting hepatitis.
has issue date	2012-06-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2012.04.011
bibo:pmid	22704621
has license	hybrid-oa
sha1sum (hex)	cecc46c7090662185f021aefe5ac236c9b888aeb
schema:url	https://doi.org/10.1016/j.chom.2012.04.011
resource representing a document's title	Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology
has PubMed Central identifier	PMC3377938
has PubMed identifier	22704621
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:cecc46c7090662185f021aefe5ac236c9b888aeb#body_text
is schema:about of	named entity 'PATHWAY' named entity 'ARTICLE' named entity 'VIRUS' named entity 'MURINE CORONAVIRUS' named entity 'HUMANS' named entity 'PATHOGENIC' named entity 'NS2' named entity 'INDUCE' named entity 'INDUCED' named entity 'FACTOR' named entity 'RNA DEGRADATION' named entity 'ACUTE HEPATITIS' named entity 'HOST' named entity '2C5' named entity 'PROTEIN ' named entity 'HEPATITIS' named entity 'RESULTING' named entity 'ACCESSORY PROTEIN' named entity 'CRITICAL' named entity 'RNASE L' named entity 'MUTANT' named entity 'BUT' named entity 'SYNTHETASE' named entity 'TO PREVENT' named entity 'ITS' named entity 'CLEAVES' named entity 'LIVER CELLS' named entity 'OLIGOADENYLATE' named entity 'UNDERSTANDING' named entity 'ENDORIBONUCLEASE' named entity 'DEFICIENT' named entity 'INTERFERON ' named entity 'VIRUSES' named entity 'HIGHLIGHTING' named entity 'PATHWAY' named entity 'PRODUCT' named entity 'NATURAL' named entity 'MECHANISMS' named entity 'IS A' named entity 'MOUSE HEPATITIS VIRUS' named entity 'LIVER' named entity 'ANTAGONISM' named entity 'NS2 PROTEIN' named entity 'VIRUS REPLICATION' named entity 'RNASE L' named entity 'OAS' named entity 'INDUCED' named entity 'INTERFERON' named entity 'MODEL' named entity 'DEVELOPMENT' named entity 'PROTECTION' named entity 'UNDERSTAND' named entity 'HIGHLY' named entity 'REPLICATE' named entity 'UNDERLYING' named entity 'MICE' named entity 'CELLULAR' named entity 'LIVER' named entity 'WILD-TYPE' named entity 'TYPE I INTERFERON' named entity 'INTERACTION' named entity 'PATHOLOGY' named entity 'ACTIVATION' named entity 'USEFUL' named entity 'BLOCKS' named entity 'PROVIDES' named entity 'NEED' named entity 'CAUSES' named entity 'OAS' named entity 'BLOCK' named entity 'VIRAL RNA' named entity 'PHOSPHODIESTERASE ACTIVITY' named entity 'REQUIRED' named entity 'MURINE CORONAVIRUS'

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