About: Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome

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About: Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome
Creator	Lei, Xiao-Ying Liu, Miao-Miao Yu, Hao Yu, Xue-Jie Zhang, Jian-Zhi
Source	Medline; PMC
abstract	BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) was an emerging hemorrhagic fever that was caused by a tick-borne bunyavirus, SFTSV. Although SFTSV nonstructural protein can inhibit type I interferon (IFN-I) production Ex Vivo and IFN-I played key role in resistance SFTSV infection in animal model, the role of IFN-I in patients is not investigated. METHODS: We have assayed the concentration of IFN-α, a subtype of IFN-I as well as other cytokines in the sera of SFTS patients and the healthy population with CBA (Cytometric bead array) assay. RESULTS: The results showed that IFN-α, tumor necrosis factor (TNF-α), granulocyte colony-stimulating factor (G-CSF), interferon-γ (IFN-γ), macrophage inflammatory protein (MIP-1α), interleukin-6 (IL-6), IL-10, interferon-inducible protein (IP-10), monocyte chemoattractant protein (MCP-1) were significantly higher in SFTS patients than in healthy persons (p < 0.05); the concentrations of IFN-α, IFN-γ, G-CSF, MIP-1α, IL-6, and IP-10 were significant higher in severe SFTS patients than in mild SFTS patients (p < 0.05). CONCLUSION: The concentration of IFN-α as well as other cytokines (IFN-γ, G-CSF, MIP-1α, IL-6, and IP-10) is correlated with the severity of SFTS, suggesting that type I interferon may not be significant in resistance SFTSV infection in humans and it may play an import role in cytokine storm.
has issue date	2017-01-13(xsd:dateTime)
bibo:doi	10.1186/s12985-016-0677-1
bibo:pmid	28086978
has license	cc-by
sha1sum (hex)	ce90f3248a2ef874c0d7cfe5926a3ca6e56a7f83
schema:url	https://doi.org/10.1186/s12985-016-0677-1
resource representing a document's title	Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome
has PubMed Central identifier	PMC5237221
has PubMed identifier	28086978
schema:publication	Virol J
resource representing a document's body	covid:ce90f3248a2ef874c0d7cfe5926a3ca6e56a7f83#body_text
is schema:about of	named entity 'CYTOKINE ' named entity 'SEVERITY' named entity 'EX VIVO' named entity 'CONCENTRATION OF' named entity 'CBA' named entity 'TICK' named entity 'HEALTHY' named entity 'PLAYED' named entity 'ANIMAL MODEL' named entity 'INTERFERON ' named entity 'PROTEIN CAN' named entity 'INFECTION' named entity 'SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME' named entity 'CORRELATION' named entity 'IFN' named entity 'CAUSED BY' named entity 'HAVE' named entity 'SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME' named entity 'INVESTIGATED' named entity 'HEMORRHAGIC FEVER' named entity 'POPULATION' named entity 'PRODUCTION' named entity 'PATIENTS' named entity 'SERA' named entity 'KEY' named entity 'SFTSV' named entity 'TYPE I INTERFERON' named entity 'ROLE' named entity 'METHODS' named entity 'ASSAY' named entity 'LEVEL WITH' named entity 'BACKGROUND' named entity 'BEAD' named entity 'RESISTANCE' named entity 'CYTOKINES' named entity 'ARRAY' named entity 'SUBTYPE' named entity 'BORNE' named entity 'BUNYAVIRUS' covid:arg/ce90f3248a2ef874c0d7cfe5926a3ca6e56a7f83 named entity 'bead' named entity 'subtype' named entity 'infection' named entity 'type I interferon' named entity 'production' named entity 'assay' named entity 'animal model' named entity 'cytokine' named entity 'IFN' named entity 'IFN' named entity 'Severe fever with thrombocytopenia syndrome' named entity 'SFTSV' named entity 'Correlation' named entity 'IFN-α' named entity 'septicemia' named entity 'tumor necrosis factor' named entity 'hemorrhagic fever' named entity 'cytokines' named entity 'CNS' named entity 'cytokine storm' named entity 'cytokines' named entity 'Windows' named entity 'cytokine storm' named entity 'leukocytes' named entity 'IL-10' named entity 'reptile' named entity 'IFN-κ' named entity 'IL-6' named entity 'IP-10' named entity 'significant difference' named entity 'RANTES' named entity 'antigen-presenting cells' named entity 'monocyte' named entity 'macrophage' named entity 'immunopathology' named entity 'acute respiratory distress syndrome' named entity 'G-CSF'

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