About: NON-WHITE ETHNICITY, MALE SEX, AND HIGHER BODY MASS INDEX, BUT NOT MEDICATIONS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ARE ASSOCIATED WITH CORONAVIRUS DISEASE 2019 (COVID-19) HOSPITALISATION: REVIEW OF THE FIRST 669 CASES FROM THE UK BIOBANK

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About: NON-WHITE ETHNICITY, MALE SEX, AND HIGHER BODY MASS INDEX, BUT NOT MEDICATIONS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ARE ASSOCIATED WITH CORONAVIRUS DISEASE 2019 (COVID-19) HOSPITALISATION: REVIEW OF THE FIRST 669 CASES FROM THE UK BIOBANK Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NON-WHITE ETHNICITY, MALE SEX, AND HIGHER BODY MASS INDEX, BUT NOT MEDICATIONS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ARE ASSOCIATED WITH CORONAVIRUS DISEASE 2019 (COVID-19) HOSPITALISATION: REVIEW OF THE FIRST 669 CASES FROM THE UK BIOBANK
Creator	Petersen, Steffen Ardissino, Maddalena Bethell, Mae Cooper, Cyrus Cooper, Jackie Harvey, Nicholas Mccracken, Celeste Raisi-Estabragh, Zahra William,
Source	MedRxiv
abstract	Background: Cardiometabolic morbidity and medications, specifically Angiotensin Converting Enzyme inhibitors (ACEi) and Angiotensin Receptor Blockers (ARBs), have been linked with adverse outcomes from coronavirus disease 2019 (COVID-19). This study aims to investigate factors associated with COVID-19 positivity for the first 669 UK Biobank participants; compared with individuals who tested negative, and with the untested, presumed negative, rest of the population. Methods: We studied 1,474 participants from the UK Biobank who had been tested for COVID-19. Given UK testing policy, this implies a hospital setting, suggesting at least moderate to severe symptoms. We considered the following exposures: age, sex, ethnicity, body mass index (BMI), diabetes, hypertension, hypercholesterolaemia, ACEi/ARB use, prior myocardial infarction (MI), and smoking. We undertook comparisons between: 1) COVID-19 positive and COVID-19 tested negative participants; and 2) COVID-19 tested positive and the remaining participants (tested negative plus untested, n=501,837). Logistic regression models were used to investigate univariate and mutually adjusted associations. Results: Among participants tested for COVID-19, non-white ethnicity, male sex, and greater BMI were independently associated with COVID-19 positive result. Non-white ethnicity, male sex, greater BMI, diabetes, hypertension, prior MI, and smoking were independently associated with COVID-19 positivity compared to the remining cohort (test negatives plus untested). However, similar associations were observed when comparing those who tested negative for COVID-19 with the untested cohort; suggesting that these factors associate with general hospitalisation rather than specifically with COVID-19. Conclusions: Among participants tested for COVID-19 with presumed moderate to severe symptoms in a hospital setting, non-white ethnicity, male sex, and higher BMI are associated with a positive result. Other cardiometabolic morbidities confer increased risk of hospitalisation, without specificity for COVID-19. Notably, ACE/ARB use did not associate with COVID-19 status.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1101/2020.05.10.20096925
has license	medrxiv
sha1sum (hex)	cd56a92cb2020dab4c1b401e95c520adf7a42994
schema:url	https://doi.org/10.1101/2020.05.10.20096925
resource representing a document's title	NON-WHITE ETHNICITY, MALE SEX, AND HIGHER BODY MASS INDEX, BUT NOT MEDICATIONS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ARE ASSOCIATED WITH CORONAVIRUS DISEASE 2019 (COVID-19) HOSPITALISATION: REVIEW OF THE FIRST 669 CASES FROM THE UK BIOBANK
resource representing a document's body	covid:cd56a92cb2020dab4c1b401e95c520adf7a42994#body_text
is schema:about of	named entity 'Enzyme inhibitors' named entity 'compared' named entity 'study' named entity 'CORONAVIRUS DISEASE' named entity 'UK Biobank' named entity 'Enzyme inhibitors' named entity 'Angiotensin Receptor Blockers' named entity 'RENIN-ANGIOTENSIN' named entity 'BIOBANK' named entity 'cardiometabolic' named entity 'hypertension' named entity 'medRxiv' named entity 'myocardial infarction' named entity 'tropism' named entity 'COVID' named entity 'epithelial cells' named entity 'medRxiv' named entity 'UK Biobank' named entity 'COVID-19' named entity 'cardiometabolic' named entity 'morbidities' named entity 'COVID-19 pandemic' named entity 'hospital settings' named entity 'Angiotensin Converting Enzyme inhibitors' named entity 'ethnicity' named entity 'ICD codes' named entity 'diabetes' named entity 'ethnicity' named entity 'morbidity' named entity 'CC-BY 4.0 International license' named entity 'non-significant' named entity 'cardiometabolic' named entity 'therapeutic targets' named entity 'BMI' named entity 'medRxiv' named entity 'kidney' named entity 'medRxiv' named entity 'COVID-19' named entity 'peer review' named entity 'metabolic' named entity 'obesity' named entity 'ACEi' named entity 'NHS' named entity 'morbidity' named entity 'CC-BY 4.0 International license' named entity 'infection' named entity 'ethnicity' named entity 'medRxiv' named entity 'developing countries' named entity 'cardiometabolic' named entity 'acute respiratory distress syndrome' named entity 'medRxiv' named entity 'comorbidity' named entity 'Coronavirus disease 2019' named entity 'infection control' named entity 'obesity' named entity 'ARBs' named entity 'COVID' named entity 'influenza infection' named entity 'COVID' named entity 'post-menopause' named entity 'CC-BY 4.0 International license' named entity 'COVID-19' named entity 'Cardiometabolic diseases' named entity 'cardiometabolic diseases' named entity 'ACEi' named entity 'COVID' named entity 'ethnicity' named entity 'obesity' named entity 'lung' named entity 'multicollinearity' named entity 'COVID' named entity 'CC-BY 4.0 International license' named entity 'medRxiv' named entity 'obesity' named entity 'rates of infection' named entity 'CC-BY 4.0 International license'

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