About: Pathogen elimination and prevention within a regulated, Designated Pathogen Free, closed pig herd for long‐term breeding and production of xenotransplantation materials

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About: Pathogen elimination and prevention within a regulated, Designated Pathogen Free, closed pig herd for long‐term breeding and production of xenotransplantation materials Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogen elimination and prevention within a regulated, Designated Pathogen Free, closed pig herd for long‐term breeding and production of xenotransplantation materials
Creator	Theis, Kara Klein, Laura Armstrong, Chasa Cooley, Kevin Hansen, Doug Martin, Mike Noordergraaf, Jeske Olson, Megan Ordway, \| Schlechter, Lisa Schucker, Adrienne Schuurman, Henk-Jan Sheffler, Marie Spizzo, \|
Source	Medline; PMC
abstract	BACKGROUND: We established a Source Animal (barrier) Facility (SAF) for generating designated pathogen‐free (DPF) pigs to serve as donors of viable organs, tissues, or cells for xenotransplantation into clinical patients. This facility was populated with caesarian derived, colostrum deprived (CDCD) piglets, from sows of conventional‐specific (or specified) pathogen‐free (SPF) health status in six cohorts over a 10‐month period. In all cases, CDCD piglets fulfilled DPF status including negativity for porcine circovirus (PCV), a particularly environmentally robust and difficult to inactivate virus which at the time of SAF population was epidemic in the US commercial swine production industry. Two outbreaks of PCV infection were subsequently detected during sentinel testing. The first occurred several weeks after PCV‐negative animals were moved under quarantine from the nursery into an animal holding room. The apparent origin of PCV was newly installed stainless steel penning, which was not sufficiently degreased thereby protecting viral particles from disinfection. The second outbreak was apparently transmitted via employee activities in the Caesarian‐section suite adjacent to the barrier facility. In both cases, PCV was contained in the animal holding room where it was diagnosed making a complete facility depopulation‐repopulation unnecessary. METHOD: Infectious PCV was eliminated during both outbreaks by the following: euthanizing infected animals, disposing of all removable items from the affected animal holding room, extensive cleaning with detergents and degreasing agents, sterilization of equipment and rooms with chlorine dioxide, vaporized hydrogen peroxide, and potassium peroxymonosulfate, and for the second outbreak also glutaraldehyde/quaternary ammonium. Impact on other barrier animals throughout the process was monitored by frequent PCV diagnostic testing. RESULT: After close monitoring for 6 months indicating PCV absence from all rooms and animals, herd animals were removed from quarantine status. CONCLUSION: Ten years after PCV clearance following the second outbreak, due to strict adherence to biosecurity protocols and based on ongoing sentinel diagnostic monitoring (currently monthly), the herd remains DPF including PCV negative.
has issue date	2018-08-18(xsd:dateTime)
bibo:doi	10.1111/xen.12428
bibo:pmid	30264879
has license	no-cc
sha1sum (hex)	c9d779b07799a189fb48a72daab15618e021fa6b
schema:url	https://doi.org/10.1111/xen.12428
resource representing a document's title	Pathogen elimination and prevention within a regulated, Designated Pathogen Free, closed pig herd for long‐term breeding and production of xenotransplantation materials
has PubMed Central identifier	PMC7169735
has PubMed identifier	30264879
schema:publication	Xenotransplantation
resource representing a document's body	covid:c9d779b07799a189fb48a72daab15618e021fa6b#body_text
is schema:about of	named entity 'industry' named entity 'transmitted' named entity 'robust' named entity 'outbreak' named entity 'negativity' named entity 'COLOSTRUM' named entity 'XENOTRANSPLANTATION' named entity 'porcine circovirus' named entity 'SAF' named entity 'suite' named entity 'cases' named entity 'derived' named entity 'nursery' named entity 'xenotransplantation' named entity 'This' named entity 'piglets' named entity 'PCV' named entity 'pathogen' named entity 'colostrum' named entity 'virus' named entity 'long-term' named entity 'infection' named entity 'donors' named entity 'PCV' named entity 'PCV2' named entity 'glutaraldehyde' named entity 'porcine circovirus' named entity 'transgenesis' named entity 'PCV' named entity 'PCR' named entity 'Genetic engineering techniques' named entity 'disinfection' named entity 'PCV' named entity 'post-weaning multisystemic wasting syndrome' named entity 'PCV' named entity 'pathogen' named entity 'quarantine' named entity 'pathogen' named entity 'weaning' named entity 'Iowa State University' named entity 'detergent' named entity 'swine' named entity 'PCV2' named entity 'PCV2' named entity 'single-stranded DNA virus' named entity 'infectious agents' named entity 'PCV' named entity 'PCV' named entity 'pathogen' named entity 'health issues' named entity 'cattle' named entity 'PERV' named entity 'immune systems' named entity 'PCR' named entity 'PCV2' named entity 'lesion' named entity 'PCV' named entity 'vaporized hydrogen peroxide' named entity 'gene' named entity 'infection' named entity 'PCV' named entity 'virus' named entity 'infection' named entity 'health screening' named entity 'disinfection' named entity 'PCV' named entity 'disinfection' named entity 'immunosuppressive'

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