About: PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity

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About: PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity
Creator	Kehn-Hall, Kylene Wu, Yuntao Akhrymuk, Ivan Freed, Eric Waheed, Abdul He, Sijia Dabbagh, Deemah Hetrick, Brian
Source	BioRxiv; Medline
abstract	P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-γ (INF-γ)-regulated factor that restricts HIV-1 infectivity, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 in virus-producing cells impairs the incorporation of SARS-CoV and SARS-CoV-2 spike (S) glycoproteins into pseudovirions and blocks virus attachment and infection of target cells. These findings suggest that PSGL-1 may potentially inhibit coronavirus replication in PSGL-1+ cells.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.073387
bibo:pmid	32511349
has license	biorxiv
sha1sum (hex)	c9d615a84da7c82b455110bf472563b3ecd698a5
schema:url	https://doi.org/10.1101/2020.05.01.073387
resource representing a document's title	PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity
has PubMed identifier	32511349
schema:publication	bioRxiv
resource representing a document's body	covid:c9d615a84da7c82b455110bf472563b3ecd698a5#body_text
is schema:about of	named entity 'surface' named entity 'expression' named entity 'inhibit' named entity 'tethering' named entity 'SARS-CoV' named entity 'Biological Sciences' named entity 'infectivity' named entity 'SARS-CoV' named entity 'VIRUS' named entity 'THESE' named entity 'binds' named entity 'PSGL-1' named entity 'Here' named entity 'antiviral' named entity 'cells' named entity 'interferon-γ' named entity 'PSGL-1' named entity 'virus' named entity 'target cells' named entity 'infectivity' named entity 'SARS-CoV' named entity 'virions' named entity 'SARS-Cov-2' named entity 'target cells' named entity 'SARS-CoV' named entity 'PSGL-1' named entity 'endothelium' named entity 'P-selectin glycoprotein ligand-1' named entity 'PSGL-1' named entity 'pseudovirus' named entity 'coronavirus' named entity 'infectivity' named entity 'lentiviral particles' named entity 'lentiviral particles' named entity 'virion' named entity 'SARS-CoV-2' named entity 'glycoproteins' named entity 'target cells' named entity 'SARS coronavirus' named entity 'Nevan Krogan' named entity 'virions' named entity 'PSGL-1' named entity 'lungs' named entity 'CD4 T cells' named entity 'SARS-CoV' named entity 'HIV-1 infection' named entity 'coronavirus disease 2019' named entity 'HIV envelope' named entity 'target cells' named entity 'protein expression' named entity 'innate immune response' named entity 'cell migration' named entity 'ISGs' named entity 'expression vector' named entity 'HIV-1 infection' named entity 'protein' named entity 'PSGL-1' named entity 'SARS-CoV' named entity 'phagocytes' named entity 'virus' named entity 'vector' named entity 'global pandemic' named entity 'SARS-CoV-2' named entity 'PSGL-1' named entity 'steric hindrance' named entity 'viral entry' named entity 'pseudotyped' named entity 'SARS-CoV-2' named entity 'luciferase' named entity 'PSGL-1' named entity '10 million people' named entity 'protein' named entity 'antiviral' named entity 'L-selectin' named entity 'pseudotype'

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