About: Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis
Creator	Laman, J Lu, J Holt, R Branton, W Lind, J Power, & Surette, M
source	PMC
abstract	Microbial communities reside in healthy tissues but are often disrupted during disease. Bacterial genomes and proteins are detected in brains from humans, nonhuman primates, rodents and other species in the absence of neurological disease. We investigated the composition and abundance of microbiota in frozen and fixed autopsied brain samples from patients with multiple sclerosis (MS) and age- and sex-matched nonMS patients as controls, using neuropathological, molecular and bioinformatics tools. 16s rRNA sequencing revealed Proteobacteria to be the dominant phylum with restricted diversity in cerebral white matter (WM) from MS compared to nonMS patients. Both clinical groups displayed 1,200–1,400 bacterial genomes/cm(3) and low bacterial rRNA:rDNA ratios in WM. RNAseq analyses showed a predominance of Proteobacteria in progressive MS patients’ WM, associated with increased inflammatory gene expression, relative to a broader range of bacterial phyla in relapsing-remitting MS patients’ WM. Although bacterial peptidoglycan (PGN) and RNA polymerase beta subunit immunoreactivities were observed in all patients, PGN immunodetection was correlated with demyelination and neuroinflammation in MS brains. Principal component analysis revealed that demyelination, PGN and inflammatory gene expression accounted for 86% of the observed variance. Thus, inflammatory demyelination is linked to an organ-specific dysbiosis in MS that could contribute to underlying disease mechanisms.
has issue date	2016-11-28(xsd:dateTime)
bibo:doi	10.1038/srep37344
bibo:pmid	27892518
has license	cc-by
sha1sum (hex)	c693f0ff2df259a716fc208b50d4d70e1d25d958
schema:url	https://doi.org/10.1038/srep37344
resource representing a document's title	Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis
has PubMed Central identifier	PMC5125007
has PubMed identifier	27892518
schema:publication	Sci Rep
resource representing a document's body	covid:c693f0ff2df259a716fc208b50d4d70e1d25d958#body_text
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