About: Lung progenitors from lambs can differentiate into specialized alveolar or bronchiolar epithelial cells

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About: Lung progenitors from lambs can differentiate into specialized alveolar or bronchiolar epithelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung progenitors from lambs can differentiate into specialized alveolar or bronchiolar epithelial cells
Creator	Abi-Rizk, Alain Archer, Fabienne Cottin, Vincent Desloire, Sophie Dolmazon, Christine Gineys, Barbara Guiguen, François Leroux, Caroline Mornex, Jean-François
Source	Medline; PMC
abstract	BACKGROUND: Airways progenitors may be involved in embryogenesis and lung repair. The characterization of these important populations may enable development of new therapeutics to treat acute or chronic lung disease. In this study, we aimed to establish the presence of bronchioloalveolar progenitors in ovine lungs and to characterize their potential to differentiate into specialized cells. RESULTS: Lung cells were studied using immunohistochemistry on frozen sections of the lung. Immunocytochemistry and flow cytometry were conducted on ex-vivo derived pulmonary cells. The bronchioloalveolar progenitors were identified by their co-expression of CCSP, SP-C and CD34. A minor population of CD34(pos)/SP-C(pos)/CCSP(pos) cells (0.33% ± 0.31) was present ex vivo in cell suspensions from dissociated lungs. Using CD34 magnetic positive-cell sorting, undifferentiated SP-C(pos)/CCSP(pos) cells were purified (>80%) and maintained in culture. Using synthetic media and various extracellular matrices, SP-C(pos)/CCSP(pos) cells differentiated into either club cells (formerly named Clara cells) or alveolar epithelial type-II cells. Furthermore, these ex vivo and in vitro derived bronchioloalveolar progenitors expressed NANOG, OCT4 and BMI1, specifically described in progenitors or stem cells, and during lung development. CONCLUSIONS: We report for the first time in a large animal the existence of bronchioloalveolar progenitors with dual differentiation potential and the expression of specialized genes. These newly described cell population in sheep could be implicated in regeneration of the lung following lesions or in development of diseases such as cancers.
has issue date	2013-11-08(xsd:dateTime)
bibo:doi	10.1186/1746-6148-9-224
bibo:pmid	24206786
has license	cc-by
sha1sum (hex)	c52ffa67fea523c74bd0c0f45033183f403692ed
schema:url	https://doi.org/10.1186/1746-6148-9-224
resource representing a document's title	Lung progenitors from lambs can differentiate into specialized alveolar or bronchiolar epithelial cells
has PubMed Central identifier	PMC3831758
has PubMed identifier	24206786
schema:publication	BMC Vet Res
resource representing a document's body	covid:c52ffa67fea523c74bd0c0f45033183f403692ed#body_text
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