About: Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis
Creator	Savarin, Carine Wang, Tian Bergmann, Cornelia Lehmann, Michael O'donnell, Lauren
Source	Medline; PMC
abstract	The central nervous system (CNS) is vulnerable to several viral infections including herpes viruses, arboviruses and HIV to name a few. While a rapid and effective immune response is essential to limit viral spread and mortality, this anti-viral response needs to be tightly regulated in order to limit immune mediated tissue damage. This balance between effective virus control with limited pathology is especially important due to the highly specialized functions and limited regenerative capacity of neurons, which can be targets of direct virus cytolysis or bystander damage. CNS infection with the neurotropic strain of mouse hepatitis virus (MHV) induces an acute encephalomyelitis associated with focal areas of demyelination, which is sustained during viral persistence. Both innate and adaptive immune cells work in coordination to control virus replication. While type I interferons are essential to limit virus spread associated with early mortality, perforin, and interferon-γ promote further virus clearance in astrocytes/microglia and oligodendrocytes, respectively. Effective control of virus replication is nonetheless associated with tissue damage, characterized by demyelinating lesions. Interestingly, the anti-inflammatory cytokine IL-10 limits expansion of tissue lesions during chronic infection without affecting viral persistence. Thus, effective coordination of pro- and anti-inflammatory cytokines is essential during MHV induced encephalomyelitis in order to protect the host against viral infection at a limited cost.
has issue date	2018-12-20(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.03022
bibo:pmid	30619363
has license	cc-by
sha1sum (hex)	c459e1a77d9256b02b2b9a5460fcfc8b420b753a
schema:url	https://doi.org/10.3389/fimmu.2018.03022
resource representing a document's title	Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis
has PubMed Central identifier	PMC6306494
has PubMed identifier	30619363
schema:publication	Front Immunol
resource representing a document's body	covid:c459e1a77d9256b02b2b9a5460fcfc8b420b753a#body_text
is schema:about of	named entity 'FOLLOWING' named entity 'astrocytes' named entity 'cytokine' named entity 'limited' named entity 'limited' named entity 'control' named entity 'response' named entity 'oligodendrocytes' covid:arg/c459e1a77d9256b02b2b9a5460fcfc8b420b753a named entity 'EARLY' named entity 'WORK IN' named entity 'NEURONS' named entity 'HIGHLY' named entity 'ANTIINFLAMMATORY' named entity 'ENCEPHALOMYELITIS' named entity 'IFN' named entity 'IL-10' named entity 'BALANCE' named entity 'NEEDS' named entity 'ASSOCIATED WITH' named entity 'NEUROTROPIC' named entity 'IMMUNE MEDIATED' named entity 'HIV' named entity 'HERPES' named entity 'VIRAL INFECTIONS' named entity 'ANTI-INFLAMMATORY CYTOKINE' named entity 'TISSUE DAMAGE' named entity 'TYPE I INTERFERONS' named entity 'REGULATED' named entity 'VIRUS' named entity 'VIRAL' named entity 'ESSENTIAL' named entity 'INDUCED' named entity 'PERFORIN' named entity 'MOUSE HEPATITIS VIRUS' named entity 'COORDINATION' named entity 'IMPORTANT' named entity 'PROMOTE' named entity 'SUSTAINED' named entity 'CAPACITY' named entity 'FINE' named entity 'NEUROTROPIC' named entity 'VULNERABLE' named entity 'CYTOKINE ' named entity 'ADAPTIVE' named entity 'VIRAL INFECTION' named entity 'SPECIALIZED' named entity 'OLIGODENDROCYTES' named entity 'ORDER' named entity 'COST' named entity 'ASTROCYTES' named entity 'CYTOLYSIS' named entity 'TO CONTROL' named entity 'IL-10' named entity 'HOST' named entity 'IMMUNE RESPONSE' named entity 'REGENERATIVE' named entity 'EXPANSION' named entity 'RAPID' named entity 'DAMAGE' named entity 'CHARACTERIZED' named entity 'IMMUNE CELLS' named entity 'AFFECTING' named entity 'INCLUDING' named entity 'VIRUS REPLICATION' named entity 'FUNCTIONS' named entity 'CHRONIC INFECTION' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'VIRUS CLEARANCE' named entity 'ACUTE' named entity 'DUE TO' named entity 'EFFECTIVE' named entity 'LESIONS' named entity 'LIMITED' named entity 'PRO-' named entity 'ANTI-VIRAL RESPONSE' named entity 'TISSUE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software