About: Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS)

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About: Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS)
Creator	Chianini, F Domingo, M Majó, N Segalés, J Domínguez, J
Source	Elsevier; Medline; PMC
abstract	The lymphoid, renal, pulmonary, and hepatic lesions of naturally occurring postweaning multisystemic wasting syndrome (PMWS) affected pigs have been studied by means of immunohistology. Ten conventionally reared pigs showing acute clinical signs of PMWS were selected from a farm on which animal were seronegative to porcine reproductive and respiratory virus and to Aujeszky’s disease virus. All pigs were positive in tests for porcine circovirus type 2 by ISH and IHC. Monoclonal and polyclonal antibodies to CD3, CD79α, CD45RA (3C3/9), lysozyme, SLA-II-DQ (BL2H5), and MAC387 were used to characterise cells in PMWS lesions. The most relevant changes were reduction or loss of B and T lymphocytes, increased numbers of macrophages, and partial loss and redistribution of antigen presenting cells throughout lymphoid tissues compared to uninfected controls. The characteristics of lymphoid lesions in the present study strongly suggest an immunosuppressive effect of PMWS in affected pigs.
has issue date	2003-07-15(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(03)00079-5
bibo:pmid	12842612
has license	no-cc
sha1sum (hex)	c3b31d45e4d5c453a34d7c2f60b8ec05dea6014f
schema:url	https://doi.org/10.1016/s0165-2427%2803%2900079-5
resource representing a document's title	Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS)
has PubMed Central identifier	PMC7119727
has PubMed identifier	12842612
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:c3b31d45e4d5c453a34d7c2f60b8ec05dea6014f#body_text
is schema:about of	named entity 'ASSOCIATE' named entity 'NATURAL' named entity 'The' named entity 'pigs' named entity 'ISH' named entity 'partial' named entity 'IHC' named entity 'compared' named entity 'lesions' named entity 'PULMONARY' named entity '27S' named entity 'LESIONS' named entity 'PRESENT' named entity 'PIGS' named entity 'SELECTED' named entity 'ACUTE' named entity 'TESTS' named entity 'AFFECTED' named entity 'IMMUNOSUPPRESSIVE EFFECT' named entity 'SLA' named entity 'REDISTRIBUTION' named entity 'CELLS' named entity 'ANIMAL' named entity 'CHANGES' named entity 'T LYMPHOCYTES' named entity 'MONOCLONAL' named entity 'FARM' named entity 'CD45RA' named entity 'RENAL' named entity 'LYMPHOID' named entity 'NATURALLY OCCURRING' named entity 'PCV2' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'COMPARED' named entity 'MEANS' named entity 'SERONEGATIVE' named entity 'LOSS OF' named entity 'ANTIGEN PRESENTING CELLS' named entity 'POLYCLONAL ANTIBODIES' named entity 'INCREASED' named entity 'CHARACTERISTICS' named entity 'REPRODUCTIVE' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'HAVE' named entity 'STUDY' named entity 'IMMUNOHISTOLOGY' named entity 'NON-' named entity 'POSITIVE' named entity 'PIGS' named entity 'POSTWEANING MULTISYSTEMIC WASTING SYNDROME' named entity 'LYMPHOID TISSUES' named entity 'PORCINE' named entity 'ISH' named entity 'SUGGEST' named entity 'USED' named entity 'CD79A' named entity 'DISEASE VIRUS' named entity 'MAC387' named entity 'NUMBERS' named entity 'HEPATIC LESIONS' named entity 'LYMPHOID TISSUES' named entity 'LYMPHOID' named entity 'LESIONS' named entity 'MACROPHAGES' named entity 'IHC' named entity 'RESPIRATORY VIRUS' named entity 'CD3' named entity 'REDUCTION' named entity 'LYSOZYME' named entity 'RELEVANT' named entity 'UNINFECTED' named entity 'PARTIAL LOSS' covid:arg/c3b31d45e4d5c453a34d7c2f60b8ec05dea6014f named entity 'pulmonary' named entity 'pigs' named entity 'selected' named entity 'T lymphocytes'

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