About: Viroporins from RNA viruses induce caspase‐dependent apoptosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viroporins from RNA viruses induce caspase‐dependent apoptosis
Creator	Carrasco, Luis Castelló, Alfredo Madan, Vanessa
Source	Medline; PMC
abstract	The virus‐encoded viroporins are known to modify membrane permeability and play an essential role in virus budding. Here, a comparative analysis of the membrane permeabilization capacity of a number of viroporins was performed in baby hamster kidney cells. Synthesis of 6K protein from Sindbis virus, E from mouse hepatitis virus, M2 from influenza A virus, and 2B and 3A from poliovirus enhanced membrane permeability to different extents. We show that two proteins from hepatitis C virus, p7 and NS4A, also display viroporin activity to a level comparable to 6K protein. In addition to their capacity to disrupt ionic cellular homeostasis and promote bacterial cell lysis, the expressed viroporins were able to induce cell death. Degradation of internucleosomal DNA and generation of apoptotic bodies were observed upon viroporin expression. Consistently, cleavage of translation initiation factor 4GI and poly‐(ADP‐ribose) polymerase indicated activation of effector caspase‐3. We found that poliovirus 2B localizes partially in mitochondria and induces an anomalous perinuclear distribution of these organelles. Mitochondria morphology was also altered after expression of other viroporins. Finally, detection of cytochrome c release from mitochondria suggests involvement of the mitochondrial pathway in viroporin‐induced apoptosis. These findings suggest that viroporins induce caspase‐dependent programmed cell death.
has issue date	2007-09-19(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2007.01057.x
bibo:pmid	17961183
has license	no-cc
sha1sum (hex)	c293fbe1117d7bf78c757091a94347044b554f92
schema:url	https://doi.org/10.1111/j.1462-5822.2007.01057.x
resource representing a document's title	Viroporins from RNA viruses induce caspase‐dependent apoptosis
has PubMed Central identifier	PMC7162385
has PubMed identifier	17961183
schema:publication	Cell Microbiol
resource representing a document's body	covid:c293fbe1117d7bf78c757091a94347044b554f92#body_text
is schema:about of	named entity 'bodies' named entity 'membrane permeability' named entity 'ionic' named entity 'number' named entity 'HAMSTER' named entity 'CELLS' named entity 'PERINUCLEAR' named entity 'POLYMERASE' named entity 'IONIC' named entity 'MITOCHONDRIAL PATHWAY' named entity 'HEPATITIS C VIRUS' named entity 'virus' named entity 'expressed' named entity 'essential' named entity 'hamster' named entity 'induces' named entity 'expression' named entity 'performed' named entity 'virus' named entity 'capacity' named entity 'poliovirus' named entity 'membrane permeability' named entity 'programmed cell death' named entity 'mitochondria' named entity 'mouse hepatitis virus' named entity 'viroporin' named entity 'NS4A' named entity 'morphology' named entity 'apoptosis' named entity 'activation' named entity 'apoptotic cells' named entity 'animal viruses' named entity 'proteolysis' named entity 'apoptosis' named entity 'caspase-3' named entity 'transcription' named entity 'Vpr' named entity 'HCV' named entity 'apoptosis' named entity 'choline' named entity 'Electroporation' named entity 'HCV' named entity 'HCV' named entity 'hydrophobic' named entity 'mammalian cells' named entity 'caspase-8' named entity 'homeostasis' named entity 'mitochondria' named entity 'BHK' named entity 'BHK' named entity 'cytochrome' named entity 'cleavage' named entity 'nuclei' named entity 'apoptosis' named entity 'IAV' named entity 'positive controls' named entity 'staining' named entity 'viral proteins' named entity 'caspase-3' named entity 'apoptosis' named entity 'protein' named entity 'restriction sites' named entity 'capsid' named entity 'membrane permeabilization' named entity 'NS4A' named entity 'capsid' named entity 'Chromatin condensation' named entity 'protein' named entity 'NS4A' named entity 'ion channels' named entity 'eIF4GI' named entity 'staining' named entity 'infection' named entity 'rat' named entity 'Huh-7' named entity 'cleavage' named entity 'transfected' named entity 'protein' named entity 'capsid'

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